Impact of a patient-support program on mesalamine adherence in patients with ulcerative colitis - A prospective study
Impact of a patient-support program on mesalamine adherence in patients with ulcerative colitis - A prospective study
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DOI：
10.1016/j.crohns.2009.10.002
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发表时间：
2010-06-01
影响因子：
8
通讯作者：
Cheifetz, Adam S.
中科院分区：
文献类型：
--
作者：
Moss, Alan C.;Chaudhary, Nabeel;Cheifetz, Adam S.
背景：据报道，溃疡性结肠炎患者对药物，特别是美沙拉嗪的依从性较低。我们试图确定护士提供的患者支持计划是否可以提高这些patients.Methods的药物治疗依从性：患者处方美沙拉嗪溃疡性结肠炎前瞻性地接受了23周，护士提供，患者支持计划（PSP）通过电话，或标准护理（SC）。服药依从性和生活质量进行了测量之前，在3个月和6个月后，程序started.Results：81例患者完成了研究，60人接受标准治疗，21人接受PSP。患者在入组时处于缓解状态（平均SCAI评分3）。SC和PSP组3个月时处方美沙拉嗪再填充的平均百分比分别为71%和74%（p = 0.7），6个月时分别为73%和84%（p = 0.4）。SC组和PSP组在3个月（39% vs 44%，p = 0.7）和6个月（50% vs 67%，p = 0.3）时的依从患者比例相似。PSP的使用与3个月（OR 1.2，95% CI 0.4 - 3.8）或6个月（OR 2，95% CI 0.6 - 7）时的依从性之间无相关性。SC组和PSP组在3个月（+0.3 vs +0.2，p = 0.8）和6个月（+0.6 vs +0.2，p = 0.2）时SIBDQ评分较基线的变化相似。结论：在短期和中期时间点，这种护士提供的患者支持计划并没有显著改善药物依从性或生活质量。在这项研究中，简单地讨论和测量依从性改善了两组的美沙拉嗪依从性。2009年欧洲克罗恩病和结肠炎组织。Elsevier B.V.出版，保留所有权利。
Background: Patient adherence to medications, particularly mesalamine, is reported to be low in patients with ulcerative colitis. We sought to determine whether a nurse-delivered patient-support program could improve medication adherence in these patients.Methods: Patients prescribed mesalamine for ulcerative colitis prospectively received either a 23 week, nurse-delivered, patient support program (PSP) by phone, or standard care (SC). Medication adherence and quality of life were measured before and at 3 and 6 months after the program started.Results: Eighty-one patients completed the study; 60 who received standard care, and 21 who received the PSP. Patients were in remission (mean SCAI score 3) at enrollment. Mean % of prescribed mesalamine refilled was 71% and 74% in the SC and PSP groups at 3 months (p=0.7), and 73% and 84% at 6 months (p = 0.4). The proportion of adherent patients at 3 months (39% vs 44%, p=0.7) and 6 months (50% vs 67%, p = 0.3) were similar between the SC and PSP groups. There was no association between use of the PSP and adherence at 3 (OR 1.2, 95% CI 0.4 to 3.8) or 6 months (OR 2, 95% CI 0.6 to 7). The change from baseline in SIBDQ scores were similar between SC and PSP groups at 3 months (+0.3 vs +0.2, p = 0.8), and 6 months (+0.6 vs +0.2, p = 0.2).Conclusions: This nurse-delivered patient-support program did not significantly improve medication adherence or quality-of-life beyond standard care at short and medium-term time-points. Simply discussing and measuring adherence improved mesalamine adherence in both groups in this study. 2009 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.