Presence and Persistence of Zika Virus RNA in Semen, United Kingdom, 2016.
Presence and Persistence of Zika Virus RNA in Semen, United Kingdom, 2016.
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DOI：
10.3201/eid2304.161692
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发表时间：
2017-04
影响因子：
11.8
通讯作者：
Aarons EJ
中科院分区：
文献类型：
--
作者：
Atkinson B;Thorburn F;Petridou C;Bailey D;Hewson R;Simpson AJ;Brooks TJ;Aarons EJ
在出现感染症状后数月收集的精液中检测到寨卡病毒RNA。鉴于寨卡病毒性传播的可能性以及妊娠期间感染导致的严重胎儿畸形，有关精液中寨卡病毒持续存在的信息对于促进我们对潜在风险的理解至关重要。我们测试了来自英国有症状男性患者的系列精液样本，这些患者被诊断为输入性寨卡病毒感染。在23例患者的初始精液样本中，13例（56.5%）检测到高水平的寨卡病毒RNA，9例（39.1%）未检测到; 1例样本（4.4%）检测不确定。症状感染后，相当比例的男性在恢复早期的精液中可检测到高拷贝数的寨卡病毒RNA，这表明性传播的风险很高。病毒RNA清除时间不一致，可能会延长。
Zika virus RNA has been detected in semen collected several months after onset of symptoms of infection. Given the potential for sexual transmission of Zika virus and for serious fetal abnormalities resulting from infection during pregnancy, information regarding the persistence of Zika virus in semen is critical for advancing our understanding of potential risks. We tested serial semen samples from symptomatic male patients in the United Kingdom who had a diagnosis of imported Zika virus infection. Among the initial semen samples from 23 patients, Zika virus RNA was detected at high levels in 13 (56.5%) and was not detected in 9 (39.1%); detection was indeterminate in 1 sample (4.4%). After symptomatic infection, a substantial proportion of men have detectable Zika virus RNA at high copy numbers in semen during early convalescence, suggesting high risk for sexual transmission. Viral RNA clearance times are not consistent and can be prolonged.