Effectiveness of Information Technology Aided Relapse Prevention Programme in Schizophrenia excluding the effect of user adherence: A randomized controlled trial
Effectiveness of Information Technology Aided Relapse Prevention Programme in Schizophrenia excluding the effect of user adherence: A randomized controlled trial
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DOI：
10.1016/j.schres.2013.08.007
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发表时间：
2013-10-01
影响因子：
4.5
通讯作者：
Iyo, Masaomi
中科院分区：
文献类型：
--
作者：
Komatsu, Hideki;Sekine, Yoshimoto;Iyo, Masaomi
背景资料：一个名为精神分裂症信息技术辅助复发预防计划（ITAREPS）的复发预防计划已经制定，据报道非常有效。然而，有效性的影响，由用户遵守协议的程序，确切的有效性和作用的ITAREPS已部分uncertaint.Objective：本研究的目的是评估的有效性的ITAREPS排除用户遵守协议的program.Method：我们试图进行随机对照试验的设计方法与访问护士服务。将门诊精神分裂症患者随机分为ITAREPS组（n = 22）和对照组（n = 23），观察12个月（2 [9.1%]）与对照组（8 [34.8%]）相比（风险比= 0.21，95% CI 0.04-0.99，p = 0.049;需要治疗的人数（NNT）= 4，95% CI 2.1-35.5）。ITAREPS组的平均住院天数（18.5天）显著低于对照组（88.8天）（p = 0.036）。ITAREPS组中再住院次数与复发次数的比率显著较低（p = 0.035），并且复发时BPRS总评分从基线的平均变化显著较小（p = 0.019）。在警告状态期间检测复发迹象并增加药物治疗是复发早期阶段的有效干预。(C)2013作者Elsevier B. V.出版，保留所有权利。
Background: A relapse prevention program called the Information Technology Aided Relapse Prevention Programme in Schizophrenia (ITAREPS) has been developed and is reported to be highly effective. However the effectiveness was influenced by user adherence to the protocol of the program, the exact effectiveness and the role of the ITAREPS have been partially uncertain.Objective: The purpose of this study is to evaluate the effectiveness of the ITAREPS excluding the effect of user adherence to the protocol of the program.Method: We attempted to perform a randomized controlled trial by the devised method with visiting nurse service. Outpatients with schizophrenia were randomized to the ITAREPS (n = 22) or control group (n = 23) and were observed for 12 months.Results: The risk of rehospitalization was reduced in the ITAREPS group (2 [9.1%]) compared with the control group (8 [34.8%]) (hazard ratio = 0.21, 95% CI 0.04-0.99, p = 0.049; number needed to treat (NNT) = 4, 95% CI 2.1-35.5). The mean number of inpatient days was significantly lower in the ITAREPS group (18.5 days) compared with the control group (88.8 days) (p = 0.036). The ratio of the number of rehospitalizations to that of relapses was significantly lower (p = 0.035) and the mean change in total BPRS scores at relapse from baseline was significantly less in the ITAREPS group (p = 0.019).Conclusions: The relapse prevention effectiveness of the ITAREPS was high, and we confirmed that the ITAREPS, i.e., detecting signs of relapse and increasing medication during the warning state, is an effective intervention during the early stages of relapse. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.