Host-microbiota interactions: epigenomic regulation.
Host-microbiota interactions: epigenomic regulation.
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DOI：
10.1016/j.coi.2016.12.001
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发表时间：
2017-02
影响因子：
7
通讯作者：
Alenghat T
中科院分区：
文献类型：
--
作者：
Woo V;Alenghat T
哺乳动物宿主及其肠道微生物群的共同进化导致了宿主微生物与哺乳动物细胞之间复杂共生关系的发展。表观基因组修饰使宿主细胞能够在不改变遗传密码的情况下改变基因表达，因此代表了哺乳动物细胞可以瞬时或稳定地转录响应环境线索的有效机制。全基因组方法的进展正在加速我们对微生物对宿主生理学影响的认识，越来越多的证据表明，表观基因组学代表了宿主整合和响应微生物信号的调节水平。特别是，细菌衍生的短链脂肪酸已经成为微生物群如何与宿主表观基因组途径相交之间的一个明确联系。在这里，我们回顾了最近的研究结果，描述在多个哺乳动物细胞群体的微生物群和表观基因组途径之间的串扰。此外，我们讨论了有趣的联系，这些联系表明我们对宿主-微生物群关系中表观基因组调节的理解范围仍处于起步阶段。
The coevolution of mammalian hosts and their commensal microbiota has led to the development of complex symbiotic relationships between resident microbes and mammalian cells. Epigenomic modifications enable host cells to alter gene expression without modifying the genetic code, and therefore represent potent mechanisms by which mammalian cells can transcriptionally respond, transiently or stably, to environmental cues. Advances in genome-wide approaches are accelerating our appreciation of microbial influences on host physiology, and increasing evidence highlights that epigenomics represent a level of regulation by which the host integrates and responds to microbial signals. In particular, bacterial-derived short chain fatty acids have emerged as one clear link between how the microbiota intersects with host epigenomic pathways. Here we review recent findings describing crosstalk between the microbiota and epigenomic pathways in multiple mammalian cell populations. Further, we discuss interesting links that suggest that the scope of our understanding of epigenomic regulation in the host-microbiota relationship is still in its infancy.