Effects of vasopressors on renal tissue gas tensions during hemorrhagic shock in dogs.
Effects of vasopressors on renal tissue gas tensions during hemorrhagic shock in dogs.
复制标题
血管加压药对犬失血性休克期间肾组织气体张力的影响。
DOI：
10.1097/00003246-198808000-00012
复制
发表时间：
1988
影响因子：
8.8
通讯作者：
A. Kobayashi
中科院分区：
文献类型：
--
作者：
K. Murakawa;A. Kobayashi
本文观察了多巴胺、肾上腺素和去甲肾上腺素对失血性休克犬肾组织气体张力变化的影响。通过使用Teflon膜质谱仪测定肾组织气体张力的变化。将动物流血的至50 mm Hg的平均动脉压（MAP）并维持1小时。然后，给予血管加压药以维持MAP高于100 mm Hg。多巴胺灌注后，肾组织氧分压（PrO 2）升高20 min，组织二氧化碳分压（PrCO 2）降低70 min，PrO 2和PrCO 2均未恢复到对照水平。当输注肾上腺素时，PrO 2最初略有一过性升高，随后逐渐下降，而PrCO 2下降30 min，然后逐渐升高。当输注去甲肾上腺素时，PrO2也出现初始轻微一过性升高，然后下降，而PrCO2一过性下降，然后迅速升高。这些结果表明，虽然多巴胺是最有用的血管加压剂，以改善肾组织气体交换在失血性休克，它并没有完全恢复氧气输送。
Effects of dopamine, epinephrine, and norepinephrine on renal tissue gas tension changes during hemorrhagic shock in dogs were investigated. The changes in the renal tissue gas tension were determined by the use of a Teflon membrane mass spectrometer. The animals were bled to a mean arterial pressure (MAP) of 50 mm Hg and maintained for one hour. Then, vasopressors were administered to maintain the MAP above 100 mm Hg. After the infusion of dopamine, the renal tissue oxygen tension (PrO2) was elevated for 20 min and tissue CO2 tension (PrCO2) decreased for 70 min. Neither PrO2 nor PrCO2 returned to the control levels. When epinephrine was infused, there was an initial slight transient rise in PrO2, which decreased gradually while PrCO2 decreased for 30 min and then gradually rose. When norepinephrine was infused, there was also an initial slight transient elevation in PrO2 which then decreased, while PrCO2 decreased transiently and then rose rapidly. These results suggest that although dopamine was the most useful vasopressor for improving renal tissue gas exchange during hemorrhagic shock, it did not restore completely oxygen delivery.