Decarboxylative Hydroamination of 3-Arylpropiolic Acids with N-Heterocycles under Transition-Metal-Free Conditions
Decarboxylative Hydroamination of 3-Arylpropiolic Acids with N-Heterocycles under Transition-Metal-Free Conditions
复制标题
无过渡金属条件下 3-芳基丙炔酸与 N-杂环的脱羧氢胺化
DOI：
10.1055/s-0033-1338622
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Xie Weiqing
中科院分区：
文献类型：
--
作者：
Pan Xixian;Wan Xiaolong;Yu Xin;Zhang Hui;Xie Weiqing
摘要 开发了3-芳基丙炔酸与N-杂环在无过渡金属条件下的脱羧加氢胺化级联反应。研究发现，3-芳基丙炔酸在 t-BuOK 的作用下可以与一系列 N-杂环顺利反应，以中等至优异的产率生成 N-乙烯基杂环。该反应代表了 3-芳基丙炔酸在不借助过渡金属催化剂的情况下的首次脱羧氢胺化。
Abstract A decarboxylative hydroamination cascade reaction of 3-arylpropiolic acids with N-heterocycles under transition-metal-free conditions was developed. 3-Arylpropiolic acids were found to react smoothly with a range of N-heterocycles under the effect of t-BuOK to afford N-vinyl heterocycles in moderate to excellent yields. This reaction represents the first decarboxylative hydroamination of 3-arylpropiolic acids without the aid of a transition-metal catalyst.