SURFACE AUDITORY EVOKED-POTENTIALS IN THE UNRESTRAINED RAT - COMPONENT DEFINITION
SURFACE AUDITORY EVOKED-POTENTIALS IN THE UNRESTRAINED RAT - COMPONENT DEFINITION
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DOI：
10.1016/0013-4694(85)91035-1
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
SIMPSON, GV
中科院分区：
文献类型：
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作者：
KNIGHT, RT;BRAILOWSKY, S;SIMPSON, GV
在不受限制的、未麻醉的大鼠中记录对短声和纯音刺激的听觉诱发电位（AEPs）。中潜伏期大鼠AEP（N17，P23，N38）具有与人类MAEP相似的中线头皮分布，并且记录到BAEP阈值以上15 dB以内。与人类MAEP相反，大鼠MAEP在高刺激率下振幅降低，只有N17成分未被慢波睡眠改变。潜伏期较长的N50、N80和P130成分具有与人类N100-P200顶点电位相当的多个响应特性。这些包括有限的中线额中央头皮分布，在ISI的幅度进行性增加高达4-8秒，并在慢波睡眠明显衰减。大鼠AEP的频率敏感性显示对低于4 kHz的纯音的反应降低，但对高达至少45 kHz的刺激的反应强烈。在大鼠听力图中，以35 kHz为中心的纯音刺激的分量振幅递减。当等同的强度，点击和纯音刺激的范围内的大鼠最大听力灵敏度（8-20 kHz）产生可比的AEP组件。这些结果提供了大鼠体表记录的AEP的标准数据。这表明，这些表面记录的大鼠AEP产生的皮层下神经系统参与检测听觉瞬态。
Auditory evoked potentials (AEPs) to click and pure tone stimuli were recorded in unrestrained, unanesthetized rats. The middle latency rat AEPs (N17, P23, N38) had midline scalp distributions similar to human MAEPs and were recorded to within 15 dB above BAEP threshold. In contrast to human MAEPs, rat MAEPs were decreased in amplitude at high stimulation rates and only the N17 component was unaltered by slow wave sleep. The longer latency N50, N80 and P130 components had several response properties comparable to human N100-P200 vertex potentials. These included restricted midline fronto-central scalp distributions, progressive increases in amplitude at ISIs up to 4-8 sec and marked attenuation during slow wave sleep. The frequency sensitivity of the rat AEP revealed a decreased response to pure tones below 4 kHz but robust responses for stimuli up to at least 45 kHz. There was a notch in the rat audiogram with decremented component amplitudes to pure tone stimuli centered at 35 kHz. When equated for intensity, click and pure tone stimuli in the range of the rats maximal audiometric sensitivity (8-20 kHz) generated comparable AEP components. These results provide normative data on rat surface recorded AEPs. It is suggested that these surface recorded rat AEPs are generated by subcortical neural systems involved in the detection of auditory transients.