Long-term treatment of rats with haloperidol:: Lack of an effect on brain N-acetyl aspartate levels
Long-term treatment of rats with haloperidol:: Lack of an effect on brain N-acetyl aspartate levels
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DOI：
10.1038/sj.npp.1300874
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发表时间：
2006-04-01
影响因子：
7.6
通讯作者：
Galloway, MP
中科院分区：
文献类型：
--
作者：
Bustillo, J;Barrow, R;Galloway, MP
质子磁共振波谱（H-1-MRS）对精神分裂症的研究表明，疾病或抗精神病药物对脑n -乙酰天冬氨酸（NAA）有影响，NAA是神经元活力的标志。我们在大鼠身上研究了氟哌啶醇对NAA、谷氨酸和谷氨酰胺的影响，在长期服药的精神分裂症患者中，有报道称代谢物减少。两组大鼠每组16只，分别给予氟哌啶醇沉积（38 mg/kg/月）和载药治疗6个月后处死。在11.7 T时，通过高分辨率魔角质子磁共振波谱（HR-MAS H-1-MRS）对以下脑区进行离体穿刺活检的代谢物浓度进行测定：内侧额叶和扣带皮层、纹状体、伏隔核、海马背侧和腹侧、杏仁核和颞叶皮层。NAA浓度的因子方差分析显示药物组无显著影响(F(1212) = 1.5；p = 0.22)或脑区相互作用组(F(7212) = 1.0；P = 0.43)。区域主效应显著(F(7212) = 17.8；p
Proton magnetic resonance spectroscopy ( H-1-MRS) studies of schizophrenia suggest an effect of the disease or of antipsychotic medications on brain N-acetyl aspartate (NAA), a marker of neuronal viability. We studied in rat the effect of haloperidol on NAA, glutamate, and glutamine in several brain regions where metabolite reductions have been reported in chronically medicated patients with schizophrenia. Two groups of 16 rats each were treated with haloperidol depo ( 38 mg/kg/month) and vehicle for 6 months and were killed. Concentrations of metabolites were determined by high-resolution magic angle proton magnetic resonance spectroscopy (HR-MAS H-1-MRS) at 11.7 T in ex-vivo punch biopsies from the following brain regions: medial frontal and cingulate cortex, striatum, nucleus accumbens, dorsal and ventral hippocampus, amygdala, and temporal cortex. Factorial ANOVA of NAA concentrations revealed no significant effect of drug group ( F( 1,212) = 1.5; p = 0.22) or a group by brain region interaction ( F( 7,212) = 1.0; p = 0.43). There was a significant main effect of region ( F( 7,212) = 17.8; p