Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures
Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures
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DOI：
10.1016/s8756-3282(97)00292-5
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发表时间：
1998-04-01
期刊：
影响因子：
4.1
通讯作者：
Lorenzo, J
中科院分区：
文献类型：
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作者：
Hurley, MM;Lee, SK;Lorenzo, J
本实验观察了碱性成纤维细胞生长因子（bFGF）对C57 BL/6小鼠骨髓破骨细胞样细胞（OCL）形成的影响。细胞在加入或不加入不同浓度bFGF或10（-8）mol/L 1，25（OH）（2）维生素D-3 [1，25（OH）（2）D-3]的情况下培养7天。与对照组相比，bFGF剂量依赖性地增加了每孔OCL的形成（10（-10）mol/L = 40 +/- 2; 10（-9）mol/L = 146 +/- 13; 10（-8）mol/L = 156 +/- 12）。
We determined the effect of basic fibroblast growth factor (bFGF) on osteoclast-like cell (OCL) formation in bone marrow cultures using C57BL/6 mice, Cells were cultured for 7 days with or without bFGF at various concentrations or 10(-8) mol/L 1,25(OH)(2) vitamin D-3 [1,25(OH)(2)D-3]. bFGF dose-dependently increased OCL formation per well (10(-10) mol/L = 40 +/- 2; 10(-9) mol/L = 146 +/- 13; 10(-8) mol/L = 156 +/- 12) compared with control (