Diabetes and Cognitive Impairment.
Diabetes and Cognitive Impairment.
复制标题
糖尿病和认知障碍。
DOI：
10.1007/s11892-016-0775-x
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发表时间：
2016-09
影响因子：
4.2
通讯作者：
Russell JW
中科院分区：
文献类型：
--
作者：
Zilliox LA;Chadrasekaran K;Kwan JY;Russell JW
1型糖尿病(T1 DM)和2型糖尿病(T2 DM)都与认知功能多个领域的表现下降以及结构和功能磁共振成像(MRI)异常的证据有关。认知缺陷可能发生在糖尿病的最早期阶段，并因代谢综合征而进一步恶化。糖尿病和血糖控制的持续时间可能会对认知损害的类型和严重程度产生影响，但到目前为止，我们还不能预测谁最有可能发生认知损害。认知障碍的病理生理学是多因素的，尽管每个相互连接的通路的功能障碍最终会导致代谢信号的不协调。其病理生理学包括胰岛素信号转导、自主神经功能、神经炎症通路、线粒体代谢、sirtuin-peroxisome增殖物激活受体-γ共激活物1α轴(sirtuin-peroxisome增殖物激活受体-γ共激活物1α)和Tau信号转导。在临床前研究中已经确定了几种有希望的治疗方法，但仍有待临床试验的验证。
Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are further exacerbated by the metabolic syndrome. The duration of diabetes and glycemic control may have an impact on the type and severity of cognitive impairment, but as yet we cannot predict who is at greatest risk of developing cognitive impairment. The patho-physiology of cognitive impairment is multifactorial, although dysfunction in each interconnecting pathway ultimately leads to discordance in metabolic signaling. The pathophysiology includes defects in insulin signaling, autonomic function, neuroinflammatory pathways, mitochondrial (Mt) metabolism, the sirtuin-peroxisome proliferator-activated receptor-gamma co-activator 1α (SIRT-PGC-1α) axis, and Tau signaling. Several promising therapies have been identified in pre-clinical studies, but remain to be validated in clinical trials.
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影响因子：
5.3
作者：
Choi, Joungil;Chandrasekaran, Krish;Demarest, Tyler G.;Kristian, Tibor;Xu, Su;Vijaykumar, Kadambari;Dsouza, Kevin Geoffrey;Qi, Nathan R.;Yarowsky, Paul J.;Gallipoli, Rao;Koch, Lauren G.;Fiskum, Gary M.;Britton, Steven L.;Russell, James W.
通讯作者：
Russell, James W.
影响因子：
--
作者：
DEVASKAR, SU;SINGH, BS;GIDDINGS, SJ
通讯作者：
GIDDINGS, SJ
影响因子：
4
作者：
Baker, Laura D.;Frank, Laura L.;Craft, Suzanne
通讯作者：
Craft, Suzanne
影响因子：
5.3
作者：
Abbott, MA;Wells, DG;Fallon, JR
通讯作者：
Fallon, JR
影响因子：
4.2
作者：
Ang, Lynn;Jaiswal, Mamta;Pop-Busui, Rodica
通讯作者：
Pop-Busui, Rodica