Overexpression of heme oxygenase-1 induced by constitutively activated NF-κB as a potential therapeutic target for activated B-cell-like diffuse large B-cell lymphoma
Overexpression of heme oxygenase-1 induced by constitutively activated NF-κB as a potential therapeutic target for activated B-cell-like diffuse large B-cell lymphoma
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由组成型激活的 NF-κB 诱导的血红素加氧酶-1 过度表达作为激活 B 细胞样弥漫性大 B 细胞淋巴瘤的潜在治疗靶点。
DOI：
10.3892/ijo.2016.3529
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发表时间：
2016-07-01
影响因子：
5.2
通讯作者：
Wang, Jishi
中科院分区：
文献类型：
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作者：
Huang, Jun;Guo, Pengxiang;Wang, Jishi
激活 B 细胞样淋巴瘤 (ABC-DLBCL) 迫切需要一种新的治疗靶点，已知这种淋巴瘤的预后不佳，并且会持续激活 NF-κ B。血红素加氧酶-1 (HO-1) 可以抑制许多癌症的细胞凋亡并促进增殖。据我们所知，尚未对 HO-1 与 DLBCL 之间的相关性进行研究。在这项研究中，对 31 例 DLBCL 患者的肿瘤组织（20 例 ABC 亚型和 11 例生发中心 B 细胞样 (GCB) 亚型）和 11 例正常淋巴结进行免疫组织化学分析，结果显示 HO-1 过表达是 ABC-DLBCL 的特征。此外，HO-1 mRNA表达水平与免疫组化结果一致。 HO-1 高水平表达与 1 个以上结外部位受累显着相关 (p=0.025)，Ki-67 阳性率较高 (p=0.025)
There is an urgent requirement for a new therapeutic target for activated B-cell-like lymphoma (ABC-DLBCL), which is known to have dismal outcome and constitutive activation of NF-kappa B. Heme oxygenase-1 (HO-1) can inhibit apoptosis and promote proliferation in many cancers. To our knowledge, no studies have been performed on the correlation between HO-1 and DLBCL. In this study, immunohistochemical analysis of 31 tumor tissues from DLBCL patients [20 of ABC subtype and 11 of germinal center B-cell-like (GCB) subtype] and 11 normal lymph nodes revealed that HO-1 overexpression was characteristic of ABC-DLBCL. In addition, HO-1 mRNA expression levels were consistent with the immunohistochemistry results. High levels of HO-1 expression were significantly correlated with the involvement of more than 1 extranodal site (p=0.025), with a high positivity rate of Ki-67 (p