[The use of drinking mineral water and low-intensity electromagnetic radiation at an early stage of metabolic syndrome development (experimental study)].
[The use of drinking mineral water and low-intensity electromagnetic radiation at an early stage of metabolic syndrome development (experimental study)].
复制标题
[在代谢综合征发展的早期阶段使用饮用矿泉水和低强度电磁辐射（实验研究）]。
DOI：
10.17116/kurort20229905154
复制
发表时间：
2022
影响因子：
--
通讯作者：
L. V. Mikhailik
中科院分区：
文献类型：
--
作者：
Y. Korolev;L. A. Nikulina;L. V. Mikhailik
研究目的
揭示实验性代谢综合征发展早期在饮用矿泉水（MW）和超高频（UHF）低强度电磁辐射（EMR）共同作用下的适应性代谢发育、光光和超微结构反应的特征。
材料和方法
该研究对 28 只体重为 180-200 克的非线性雄性大鼠进行。以高热量饮食为背景的实验组动物首先（从实验第8天开始）接受一个疗程的MW硫酸盐饮用（24个程序），并在完成后接受一个疗程的低强度EMR UHF（12个程序），每天，使用Aquaton-2设备（功率通量密度1μW/cm2，频率1000MHz）在肾上腺的区域投影中每个腰部区域2分钟。只喂食高热量饮食的动物作为对照；还使用了完整的动物。研究对象是肝脏、血液、胸腺。使用生物化学、组织学、电子显微镜和形态测量研究方法。
结果与讨论
饮用MW和低强度UHF EMR的结合使用有助于适应性代谢和再生过程的发展：血液中葡萄糖和高密度脂蛋白的水平降低，肝脏中的抗氧化活性明显增加，RNA、DNA和总蛋白的含量增加，营养不良和坏死细胞的数量减少。细胞内再生过程的加强表现为线粒体、过氧化物酶体以及蛋白质合成细胞器（核糖体和多聚体）数量的增加。溶酶体系统的功能活性增加。胸腺中的细胞核数量增加，胸腺细胞基因组的比活性也增加。所揭示的作用主要是由于 MW 和 UHF EMR 的抗氧化、膜稳定、解毒和免疫调节作用。
结论
根据获得的数据，可以得出结论，鉴于在代谢综合征发展的早期阶段治疗和预防新方法的开发，饮用MW和低强度UHF EMR的联合使用非常有前景。为了优化适应性保护和补偿过程，应使用更适当的组合暴露于 MW 和 UHF EMR 的模式。
PURPOSE OF THE STUDY
To reveal the features of adaptive metabolic development, light-optical and ultrastructural reactions under the combined action of drinking mineral water (MW) and low-intensity electromagnetic radiation (EMR) of ultrahigh frequency (UHF) at an early stage of development of the experimental metabolic syndrome.
MATERIAL AND METHODS
The study was performed on 28 non-linear male rats weighing 180-200 g. Animals of the experimental group on the background of a high-calorie diet received at first (from the 8th day of the experiment) a course of drinking sulfate MW (24 procedures), and after its completion - a course of low-intensity EMR UHF (12 procedures), daily, 2 minutes per lumbar region in the zone projections of the adrenal glands using the Aquaton-2 device (power flux density 1 μW/cm2, frequency 1000 MHz). Animals fed only a high-calorie diet served as controls; intact animals were also used. The objects of study were the liver, blood, thymus. Biochemical, histological, electron microscopic and morphometric research methods were used.
RESULTS AND DISCUSSION
The combined use of drinking MW and low-intensity UHF EMR contributed to the development of adaptive metabolic and regenerative processes: the level of glucose and high-density lipoproteins decreased in the blood, antioxidant activity clearly increased in the liver, the content of RNA, DNA and total protein increased, and the number of dystrophic and necrobiotic cells decreased. Strengthening of the processes of intracellular regeneration was manifested in an increase in the number of mitochondria, peroxisomes, as well as protein-synthesizing organelles - ribosomes and polysomes. Functional activity of the lysosomal system increased. The number of nuclei increased In thymus and specific activity of the thymocyte genome increased as well. The revealed effects were mainly due to the antioxidant, membrane stabilizing, detoxifying, and immunomodulatory effects of MW and UHF EMR.
CONCLUSION
Based on the data obtained, it can be concluded that the combined use of drinking MW and low-intensity UHF EMR can be very promising in the light of the development of new approaches to the treatment and prevention of metabolic syndrome in the early stages of its development. To optimize the adaptive-protective and compensatory processes, more adequate modes of combined exposure to MW and UHF EMR should be used.