CONDITIONED PLACE PREFERENCE PRODUCED BY INFUSION OF MET-ENKEPHALIN INTO THE MEDIAL PREOPTIC AREA
CONDITIONED PLACE PREFERENCE PRODUCED BY INFUSION OF MET-ENKEPHALIN INTO THE MEDIAL PREOPTIC AREA
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DOI：
10.1016/0006-8993(91)91339-3
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发表时间：
1991-06-07
期刊：
影响因子：
2.9
通讯作者：
GOMEZ, M
中科院分区：
文献类型：
--
作者：
AGMO, A;GOMEZ, M
条件位置偏好程序用于评估 D-Ala2-Met5-脑啡酰胺 (DALA) 双侧输注至内侧视前区后的奖励特性。使用的剂量为 60、250 和 1000 ng/插管。结果发现，所有剂量的 DALA 都会产生位置偏好。这表明内侧视前区是一个结构，其中阿片类奖励的剂量与已建立的奖励系统所需的剂量一样低。讨论了这与性奖励相关的重要性。
The conditioned place preference procedure was used to evaluate the rewarding properties of D-Ala2-Met5-enkephalinamide (DALA) after bilateral infusion into the medial preoptic area. Doses of 60, 250 and 1000 ng/cannula were used. It was found that all doses of DALA produced place preference. This suggests that the medial preoptic area is a structure where opioid reward is produced in doses as low as those required in already established reward systems. The significance of this in relation to sexual reward is discussed.