Electrophysiologic Effects of Enflurane and Halothane on Isolated Rabbit Hearts in the Presence and Absence of Metabolic Acidosis
Electrophysiologic Effects of Enflurane and Halothane on Isolated Rabbit Hearts in the Presence and Absence of Metabolic Acidosis
复制标题
安氟烷和氟烷对存在和不存在代谢性酸中毒的离体兔心脏的电生理影响
DOI：
10.1213/00000539-198511000-00004
复制
发表时间：
1985
影响因子：
5.7
通讯作者：
M. Kanno
中科院分区：
文献类型：
--
作者：
S. Ozaki;Y. Gotoh;H. Nakaya;M. Azuma;M. Kanno
在恒速灌流的离体兔心脏上，观察了氟烷和安氟醚在正常pH条件下和代谢性酸中毒时的电生理效应。在正常pH条件下，氟烷和安氟醚均对窦房结自律性和房室传导产生浓度依赖性抑制。在2MAC时，持续起搏时的房室内传导时间略有延长，但显著延长。在相同的MAC下，这些电生理变化的幅度与氟烷和安氟醚相似。这些电生理效应在代谢性酸中毒(pH 6.9)时更加明显。这些结果表明，安氟醚和氟烷对心脏传导系统有直接的抑制作用，代谢性酸中毒可能会增强这种电生理作用。
Electrophysiologic effects of halothane and enflurane in the presence of a normal pH and during metabolic acidosis were examined in isolated rabbit hearts perfused at a constant rate. During exposure to a normal pH, both halothane and enflurane produced concentration-dependent suppression of sinus node automaticity and atrioventricular conduction. Intraatrial and intraventricular conduction times during constant pacing were slightly but significantly prolonged by these anesthetics at 2 MAC. The magnitudes of these electrophysiologic changes were similar with halothane and enflurane when compared at the same MAC. These electro-physiologic effects became more marked during metabolic acidosis (pH 6.9). These results suggest that enflurane and halothane have direct depressant actions on the cardiac conduction system and that these electrophysiologic effects may be augmented by metabolic acidosis.