Does interstitial lung disease predispose to lung cancer?
Does interstitial lung disease predispose to lung cancer?
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DOI：
10.1097/01.mcp.0000170521.71497.ba
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发表时间：
2005-09-01
影响因子：
3.3
通讯作者：
Jett, JR
中科院分区：
文献类型：
--
作者：
Daniels, CE;Jett, JR
本文综述了肺癌与间质性肺疾病相关的因果关系和发病机制的证据。虽然吸烟是导致肺癌的主要原因，但其他几种情况或易导致肺癌，或增加吸烟者患肺癌的风险。有证据表明，由于特发性肺纤维化、系统性硬化症和某些尘肺病等特异性纤维化和炎症性肺病（称为间质性肺病），肺癌风险增加。潜在的发病机制表明，复发性损伤和炎症导致易患肺癌的遗传改变。特发性肺纤维化、系统性硬化症和某些尘肺病与肺癌风险增加相关；然而，没有一个统一的发病机制来解释这种关联的因果关系。此外，不一致的肺癌发病率报告引起了对高质量前瞻性研究的关注。
Purpose of review This review examines the evidence for the causality and pathogenesis of lung cancer associated with interstitial lung disease.Recent findings Although cigarette smoking is the leading cause of lung cancer, several other conditions either predispose to lung cancer or increase the risk of lung cancer in smokers. The evidence supports an increased risk of lung cancer due to specific fibrotic and inflammatory lung diseases (termed interstitial lung diseases), including idiopathic pulmonary fibrosis, systemic sclerosis, and certain pneumoconioses. The potential pathogenetic mechanisms indicate that recurrent injury and inflammation result in genetic alterations that predispose to lung cancer.Summary Idiopathic pulmonary fibrosis, systemic sclerosis, and certain pneumoconioses are associated with an independent increased risk of lung cancer; however, a unifying pathogenetic mechanism to explain the causality of this association has not been described. In addition, the inconsistently reported lung cancer frequencies call attention to the need for prospective studies of good quality.