Molecular Cancer
Molecular Cancer
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发表时间：
2009
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影响因子：
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通讯作者：
Xiaowei Sun;R. Essalmani;N. Seidah;A. Prat
中科院分区：
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作者：
Xiaowei Sun;R. Essalmani;N. Seidah;A. Prat
研究原蛋白转换酶PC5/6对肠道肿瘤的保护作用：活体小鼠模型研究背景：分泌型碱性氨基酸特异性原蛋白转换酶(PC)常与肿瘤/转移有关。通过控制癌症相关蛋白的裂解，PC在癌症发展的多个步骤中发挥关键作用。大多数关于PC在癌症/转移中的作用的分析依赖于体外过表达系统或抑制剂的使用，这些系统或抑制剂可以影响不止一种PC。除了呋喃在唾液腺肿瘤发生中的作用外，没有其他体内PC基因敲除模型与癌症发生有关的报道。
Research The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model Abstract Background: The secretory basic amino acid-specific proprotein convertases (PCs) have often been associated with cancer/metastasis. By controlling the cleavage of cancer-associated proteins, PCs play key roles in multiple steps of cancer development. Most analyses of the implication of PCs in cancer/metastasis relied on the use of in vitro overexpression systems or inhibitors that can affect more than one PC. Aside from the role of furin in salivary gland tumorigenesis, no other in vivo genetic model of PC-knockout was reported in relation to cancer development.