Self-assembled two-dimensional protein arrays in bionanotechnology: from S-layers to designed lattices.

Self-assembled two-dimensional protein arrays in bionanotechnology: from S-layers to designed lattices.
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DOI:
10.1016/j.copbio.2013.11.001
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发表时间:
2014-08
影响因子:
7.7
通讯作者:
Matthaei, James F.
Matthaei, James F.
中科院分区:
工程技术1区
文献类型:
--
作者:
Baneyx, Francois;Matthaei, James F.

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虽然形成许多古生菌和细菌外骨骼的晶体s层阵列已经研究了几十年,但人们期待已久的晶体结构加上对s层组装过程的日益了解正在为该领域注入新的兴奋。这种趋势被计算机策略所放大,计算机策略允许在计算机上设计能够自组装成二维晶格和其他规定的四级结构的蛋白质构建块。我们回顾了这些和其他最近的发展,以实现从纳米到中尺度对基于蛋白质的二维物体的几何、化学和功能的无与伦比的控制。
Although the crystalline S-layer arrays that form the exoskeleton of many archaea and bacteria have been studied for decades, a long-awaited crystal structure coupled with a growing understanding of the S-layer assembly process are injecting new excitement in the field. The trend is amplified by computational strategies that allow for in silico design of protein building blocks capable of self-assembling into 2D lattices and other prescribed quaternary structures. We review these and other recent developments towards achieving unparalleled control over the geometry, chemistry and function of protein-based 2D objects from the nano- to the mesoscale.
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