HUMAN PAPILLOMAVIRUS IN BREAST-CANCER
HUMAN PAPILLOMAVIRUS IN BREAST-CANCER
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DOI：
10.1007/bf01836955
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发表时间：
1992-01-01
影响因子：
3.8
通讯作者：
MARCANTE, ML
中科院分区：
文献类型：
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作者：
DILONARDO, A;VENUTI, A;MARCANTE, ML
从石蜡包埋的乳腺癌和腋窝淋巴结的组织切片进行了检查的人乳头瘤病毒的存在下，通过两种不同的技术：聚合酶链反应（PCR）和原位杂交与生物素标记的探针。通过PCR，我们在29.4%的乳腺肿瘤和一些转移性淋巴结中检测到HPV 16 DNA序列，尽管我们无法通过原位杂交鉴定任何HPV DNA序列。这些结果表明HPV可能在乳腺肿瘤的发生中发挥作用。
Histological sections from paraffin-embedded breast carcinoma and axillary lymph nodes were examined for the presence of human papillomaviruses by two different techniques: the polymerase chain reaction (PCR) and the in situ hybridization with biotin-labelled probes. By PCR we detected HPV 16 DNA sequences in 29.4% of breast tumours and in some metastatic lymph nodes, though we were unable to identify any HPV DNA sequences by in situ hybridization. These results suggest that HPV's could play a role in the genesis of breast neoplasia.