Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling Hispanic and non-Hispanic older adults
Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling Hispanic and non-Hispanic older adults
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DOI：
10.1017/s1355617704103020
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发表时间：
2004-05-01
影响因子：
2.6
通讯作者：
Jagust, WJ
中科院分区：
文献类型：
--
作者：
Farias, ST;Mungas, D;Jagust, WJ
本研究的目的是探讨基于特定信息提供者的日常功能测量，即老年人认知衰退信息收集问卷（IQCODE；Jorm & Korten，1988）与大量多文化、多语言白种人和西班牙裔样本中的认知和结构神经影像的关系。认知变量包括从西班牙语和英语神经心理学评估量表（SENAS；Mungas 等，2000）中选定的子测试：言语记忆、物体命名、言语注意力广度、言语概念思维和模式识别。在讲英语和西班牙语的西班牙裔个体的子样本中评估了 IQCODE 与选定的神经影像变量、海马体积和白质高信号之间的关联。尽管只有语言记忆和物体命名独立预测功能能力水平，但认知变量与 IQCODE 表现出很强的双变量关系。言语记忆是功能状态最强的预测因子，占 IQCODE 方差的 23%。白质高信号也与 IQCODE 独立相关，占方差的 18%。在简单的双变量分析中，海马体积与 IQCODE 相关，但在控制年龄后并不是报告的功能状态的独立预测因子。认知变量和功能状态之间的关系，以及成像变量和 IQCODE 之间的关系，在不同语言族群之间没有差异。
The purpose of this study was to examine how a specific informant-based measure of everyday functioning, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE; Jorm & Korten, 1988) relates to cognition and structural neuroimaging in a large multicultural, multilingual sample of Caucasians and Hispanics. Cognitive variables included selected subtests from the Spanish and English Neuropsychological Assessment Scales (SENAS; Mungas et al., 2000): Verbal Memory, Object Naming, Verbal Attention Span, Verbal Conceptual Thinking, and Pattern Recognition. The association between the IQCODE and selected neuroimaging variables, hippocampal volume and white matter hyperintensity, was evaluated in a subsample of English- and Spanish-speaking Hispanic individuals. The cognitive variables showed strong bivariate relationships with the IQCODE, although only Verbal Memory and Object Naming independently predicted level of functional ability. Verbal Memory was the strongest predictor of functional status, accounting for 23% of the variance in the IQCODE. White matter hyperintensity was also independently related to the IQCODE, accounting for 18% of the variance. Hippocampal volume was related to the IQCODE in a simple bivariate analysis, but was not an independent predictor of reported functional status after controlling for age. The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups.