Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the gerbil: relation to induction of HSP70.
Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the gerbil: relation to induction of HSP70.
复制标题
盐酸比非美烷对沙鼠缺血性海马 CA1 神经元损伤的保护作用：与 HSP70 诱导的关系。
DOI：
10.1016/0024-3205(93)90663-n
复制
发表时间：
1993
期刊：
影响因子：
6.1
通讯作者：
K. Kogure
中科院分区：
文献类型：
--
作者：
X. Liu;K. Abe;M. Aoki;T. H. Lee;H. Kato;K. Kogure
研究了盐酸联苯美仑(BF)对短暂性前脑缺血后沙土鼠海马CA1区神经元死亡的保护作用，其机制与诱导70kd热休克蛋白(HSP70)及其mRNA的表达有关。组织学检查显示，BF 10 mg/kg和30 mg/kg组大鼠海马CA1区神经元密度明显高于对照组(P<0.05)。缺血后7天高于模型组(分别为P<；0.05和P<；0.01)。HSP70蛋白免疫组织化学和原位杂交结果显示，BF(30 mg/kg)处理组大鼠脑内HSP70及其mRNA的诱导与赋形剂组相比明显减少和受限。这些数据表明，BF对脆弱的CA1神经元具有保护作用。并对可能的保护机制进行了讨论。
A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p<0.05 and p<0.01, respectively) at 7 days after ischemia. Immunohistochemistry against HSP70 protein andin situhybridization for the mRNA revealed that the inductions of immunoreactive HSP70 and the mRNA were remarkably reduced and limited in the brain hippocampi treated with BF (30 mg/kg) as compared with vehicle-treated animals. These data indicate that BF possesses a protective effect against ischemic injury to the vulnerable CA1 neurons. The possible mechanisms of the protection are discussed.