Enhancing Tabletop X-Ray Phase Contrast Imaging with Nano-Fabrication.
Enhancing Tabletop X-Ray Phase Contrast Imaging with Nano-Fabrication.
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DOI：
10.1038/srep13581
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发表时间：
2015-08-28
影响因子：
4.6
通讯作者：
Wen H
中科院分区：
文献类型：
--
作者：
Miao H;Gomella AA;Harmon KJ;Bennett EE;Chedid N;Znati S;Panna A;Foster BA;Bhandarkar P;Wen H
x射线相衬成像在提高软组织造影剂和降低生物医学应用中的辐射剂量方面是一种很有前途的方法。虽然目前的桌面成像系统通过采用吸收元件（如吸收光栅或单片晶体）来过滤光束，以适应普通x射线管和大面积探测器，但我们开发了纳米相位光栅，使桌面x射线远场干涉测量仅使用相移元件，从而大大增强了相衬成像的性能。在一般意义上，该方法将对x射线源空间相干性和探测器分辨率的要求转移到x射线相位掩模的特征尺寸上。我们展示了其在临床剂量水平的一小部分硬x射线成像实验中的能力，并与现有的塔尔博特-劳干涉仪和传统的数字射线照相进行了比较。
X-ray phase-contrast imaging is a promising approach for improving soft-tissue contrast and lowering radiation dose in biomedical applications. While current tabletop imaging systems adapt to common x-ray tubes and large-area detectors by employing absorptive elements such as absorption gratings or monolithic crystals to filter the beam, we developed nanometric phase gratings which enable tabletop x-ray far-field interferometry with only phase-shifting elements, leading to a substantial enhancement in the performance of phase contrast imaging. In a general sense the method transfers the demands on the spatial coherence of the x-ray source and the detector resolution to the feature size of x-ray phase masks. We demonstrate its capabilities in hard x-ray imaging experiments at a fraction of clinical dose levels and present comparisons with the existing Talbot-Lau interferometer and with conventional digital radiography.