Memory expression is independent of memory labilization/reconsolidation
Memory expression is independent of memory labilization/reconsolidation
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DOI：
10.1016/j.nlm.2013.10.006
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发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Delorenzi, Alejandro
中科院分区：
文献类型：
--
作者：
Barreiro, Karina A.;Suarez, Luis D.;Delorenzi, Alejandro
越来越多的证据表明，某些重新启动条件既限制了不稳定阶段的开始，也限制了重新稳定进程或重新巩固的开始。然而，目前尚不清楚提取过程中记忆表达的变化如何影响标记/再巩固过程的出现。为了解决这个问题，我们使用了查斯马纳瑟斯的语境-信号记忆模型。在这个范例中，不包括强化的简短提醒允许我们评估记忆的稳定和再巩固，而简短但强化的提醒限制了这一过程的开始。目前的研究调查了谷氨酸拮抗剂APV(0.6或1.5微克/克)和CNQX(1微克/克)在提醒会议之前对行为表达和再巩固过程的影响。在提醒不启动稳定化/再巩固过程的条件下，APV阻止了记忆的表达，而不影响长期记忆保持。相反，当在触发重新巩固的提醒会议之前给药时，APV在长期内会导致健忘效应。在目前的参数条件下，在允许记忆进入再巩固的提醒之前给予CNQX会在不干扰记忆表达的情况下损害这一过程。总体而言，目前的发现表明，记忆的重新激活--但不是记忆的表达--是稳定和重新巩固所必需的。因此，提取和记忆表达似乎不是可以互换的概念。(C)2013 Elsevier Inc.保留所有权利。
There is growing evidence that certain reactivation conditions restrict the onset of both the destabilization phase and the restabilization process or reconsolidation. However, it is not yet clear how changes in memory expression during the retrieval experience can influence the emergence of the labilization/reconsolidation process. To address this issue, we used the context-signal memory model of Chasmagnathus. In this paradigm a short reminder that does not include reinforcement allows us to evaluate memory labilization and reconsolidation, whereas a short but reinforced reminder restricts the onset of such a process. The current study investigated the effects of the glutamate antagonists, APV (0.6 or 1.5 mu g/g) and CNQX (1 mu g/g), prior to the reminder session on both behavioral expression and the reconsolidation process. Under conditions where the reminder does not initiate the labilization/reconsolidation process, APV prevented memory expression without affecting long-term memory retention. In contrast, APV induced amnesic effects in the long-term when administered before a reminder session that triggers reconsolidation. Under the present parametric conditions, the administration of CNQX prior to the reminder that allows memory to enter reconsolidation impairs this process without disrupting memory expression. Overall, the present findings suggest that memory reactivation - but not memory expression- is necessary for labilization and reconsolidation. Retrieval and memory expression therefore appear not to be interchangeable concepts. (C) 2013 Elsevier Inc. All rights reserved.