Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections.
Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections.
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DOI：
10.4254/wjh.v8.i31.1295
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发表时间：
2016-11-08
影响因子：
2.4
通讯作者：
Muga R
中科院分区：
文献类型：
--
作者：
Fuster D;Sanvisens A;Bolao F;Rivas I;Tor J;Muga R
酒精使用障碍（AUD）和丙型肝炎病毒（HCV）感染经常同时发生。AUD与HCV感染的暴露量增加、HCV感染持续性增加以及由于AUD与HCV之间在免疫应答、细胞毒性和氧化应激方面的相互作用而导致的更广泛的肝损伤相关。虽然AUD和HCV感染与发病率和死亡率增加相关，但HCV抗病毒治疗在患有这两种疾病的个体中不太常见。AUD在人类免疫缺陷病毒（HIV）感染中也很常见，这对适当的HIV护理和坚持抗逆转录病毒治疗以及肝脏疾病产生了负面影响。此外，AUD和HCV感染在一定比例的HIV感染患者中也很常见，这对肝脏疾病产生了负面影响。本文综述了目前关于AUD与丙型肝炎感染、HIV感染和HCV/HIV合并感染的病理相互作用以及这些个体中AUD治疗干预的相关知识。
Alcohol use disorder (AUD) and hepatitis C virus (HCV) infection frequently co-occur. AUD is associated with greater exposure to HCV infection, increased HCV infection persistence, and more extensive liver damage due to interactions between AUD and HCV on immune responses, cytotoxicity, and oxidative stress. Although AUD and HCV infection are associated with increased morbidity and mortality, HCV antiviral therapy is less commonly prescribed in individuals with both conditions. AUD is also common in human immunodeficiency virus (HIV) infection, which negatively impacts proper HIV care and adherence to antiretroviral therapy, and liver disease. In addition, AUD and HCV infection are also frequent within a proportion of patients with HIV infection, which negatively impacts liver disease. This review summarizes the current knowledge regarding pathological interactions of AUD with hepatitis C infection, HIV infection, and HCV/HIV co-infection, as well as relating to AUD treatment interventions in these individuals.