Intracellular stimulation of an identified neuron evokes cardioacceleratory peptide release.
Intracellular stimulation of an identified neuron evokes cardioacceleratory peptide release.
复制标题
对已识别的神经元进行细胞内刺激会引起心脏加速肽的释放。
DOI：
10.1126/science.4001929
复制
发表时间：
1985
期刊：
影响因子：
56.9
通讯作者：
J. Truman
中科院分区：
文献类型：
--
作者：
N. Tublitz;J. Truman
烟草天蛾（Manduca sexta）的中枢神经系统已知含有两种心脏加速肽（CAP），这两种肽在体内作为心脏调节神经激素起作用。单个腹神经节神经元的细胞内电刺激引起CAP样生物活性的释放。这种刺激诱发的生物活性被预先用蛋白酶处理破坏。细胞内刺激含CAP的神经元突触激活额外的尖峰神经元的可能性被消除。
The central nervous system of the tobacco hawkmoth, Manduca sexta, is known to contain two cardioacceleratory peptides (CAP's), both of which function in vivo as cardioregulatory neurohormones. Intracellular electrical stimulation of a single abdominal ganglion neuron evokes the release of CAP-like bioactivity. This stimulation-evoked bioactivity is destroyed by prior treatment with protease. The possibility that intracellular stimulation of a CAP-containing neuron synaptically activated additional spiking neurons is eliminated.