Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles
Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles
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DOI：
10.1038/s41598-017-02508-3
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发表时间：
2017-05-19
影响因子：
4.6
通讯作者：
Melancon, Marites P.
中科院分区：
文献类型：
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作者：
Tian, Li;Lee, Patrick;Melancon, Marites P.
未能取出可回收的下腔静脉滤器可能会导致严重的并发症和高昂的治疗费用。聚二氧杂环己酮(PPDO)已被证明是一种很好的可吸收下腔静脉滤器的候选材料。然而，在传统的成像方式下，PPDO是放射偏振的。因此，这些PPDO滤光片的位置和完整性不能通过计算机断层扫描(CT)或X射线进行监测。在这里，我们报告了基于金纳米颗粒(AuNPs)的不透射线的PPDO IVC滤光片的发展。将市售的PPDO缝线注入AuNPs。扫描电子显微镜分析证实了PPDO表面存在AuNP。与未经处理的PPDO缝合线相比，注入AuNP的PPDO缝合线的Micro-CT和X光图像显示显著的信号增强。元素分析表明，金的负载量超过2000ppm。注射AuNP的PPDO的抗张强度和体外细胞毒性与未处理的PPDO无显著差异。在10周的稳定性研究中，注入的PPDO缝线的金含量和放射不透明度在前6周都没有明显变化。注入AuNP的PPDO缝线的衰减增加表明其作为一种不透射线的可吸收过滤材料的主要优势，因为其不透射线可以监测过滤器的位置和完整性，从而提高其安全性和有效性。
Failure to remove a retrievable inferior vena cava (IVC) filter can cause severe complications with high treatment costs. Polydioxanone (PPDO) has been shown to be a good candidate material for resorbable IVC filters. However, PPDO is radioluscent under conventional imaging modalities. Thus, the positioning and integrity of these PPDO filters cannot be monitored by computed tomography (CT) or x-ray. Here we report the development of radiopaque PPDO IVC filters based on gold nanoparticles (AuNPs). Commercially available PPDO sutures were infused with AuNPs. Scanning electron microscopy analysis confirmed the presence of AuNP on the surface of PPDO. Micro-CT and x-ray images of the AuNP-infused PPDO sutures showed significant signal enhancement compared to untreated PPDO sutures. Elemental analysis showed that gold loading exceeded 2000 ppm. Tensile strength and in vitro cytotoxicity showed no significant difference between AuNP-infused and untreated PPDO. In a 10-week stability study, neither the gold content nor the radiopacity of the infused PPDO sutures significantly changed in the first 6 weeks. The increased attenuation of AuNP-infused PPDO sutures indicates their major advantage as a radiopaque resorbable filter material, as the radiopacity allows monitoring of the position and integrity of the filter, thereby increasing its safety and efficacy.