Neuromyelitis optica in patients with coexisting human immunodeficiency virus infections
Neuromyelitis optica in patients with coexisting human immunodeficiency virus infections
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DOI：
10.1177/1352458513483891
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发表时间：
2013-09-01
影响因子：
5.8
通讯作者：
Smith, Robert G.
中科院分区：
文献类型：
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作者：
Feyissa, Anteneh M.;Singh, Parbhdeep;Smith, Robert G.
两名已知感染人类免疫缺陷病毒（HIV）并接受抗逆转录病毒治疗的患者出现视神经肌萎缩症（Devic病）。1例患者血清水通道蛋白-4免疫球蛋白G抗体检测呈阳性。两名患者均在发病时和疾病复发期间接受高剂量静脉内脉冲甲基强的松龙治疗，随后进行标准血浆置换。对于维持治疗，1例患者接受利妥昔单抗输注，第二例患者接受吗替麦考酚酯口服。尽管接受了治疗，但两名患者目前仍因严重下肢轻瘫而坐在轮椅上。视神经肌萎缩症可在HIV感染过程中发生，并构成持续的治疗挑战。
Two patients with known human immunodeficiency virus (HIV) infections and receiving antiretroviral treatment developed neuromyelitis optica (Devic's disease). One patient tested positive for serum aquaporin-4 immunoglobulin G antibodies. Both patients were treated with high dose pulsed intravenous methylprednisolone followed by standard sessions of plasma exchange both at the onset attack and during disease relapses. For maintenance therapy, one patient received rituximab infusions and the second patient received mycophenolate mofetil orally. Despite treatment, both patients are currently wheelchair-bound due to severe paraparesis. Neuromyelitis optica can occur in the course of HIV infection and poses an ongoing therapeutic challenge.