Physical Performance in a Diverse, Population-Based Cohort of Individuals With Systemic Lupus Erythematosus.
Physical Performance in a Diverse, Population-Based Cohort of Individuals With Systemic Lupus Erythematosus.
复制标题
不同人群的系统性红斑狼疮患者的身体表现。
DOI：
10.1002/acr.25266
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发表时间：
2024
影响因子：
4.7
通讯作者：
Drenkard,Cristina
中科院分区：
文献类型：
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作者：
Plantinga,LauraC;Bowling,CBarrett;Hoge,Courtney;Dunlop-Thomas,Charmayne;Pearce,BradleyD;Lim,SSam;Drenkard,Cristina
目的报道不同人群系统性红斑狼疮（SLE）患者身体表现不佳的负担及其相关因素。方法在这项来自亚特兰大大都会人群的446例SLE患者的单次就诊研究中，我们通过短体能测试（评分范围0-12；中低[<10]vs高[≥10]）测量了身体表现。我们还收集了人口统计学、临床和社会心理变量，并通过多变量logistic回归检验了中低与高体力表现与这些特征之间的关联（调整优势比[aORs]）。结果我们发现，超过一半（59.6%）的参与者整体体能表现较差（中低）。只有7%的队列在下肢力量任务中获得最高分，而90%和76%的队列在平衡和步态速度任务中获得最高分。当前的就业状况（aOR 0.69, 95%可信区间[CI] 0.45-1.05）和较高的认知功能（aOR 0.57, 95% CI 0.42-0.77）与中低体力表现的较低几率密切相关。较高的身体质量指数（aOR 1.25, 95% CI 1.01-1.56）、疾病活动性（aOR 1.59, 95% CI 1.27-1.98）和疾病负担（aOR 1.38, 95% CI 1.08-1.77）与较差的表现相关，同样与较高的抑郁症状、感知压力得分和较低的受教育程度相关（无统计学意义）。结论：在我们以人群为基础的主要是黑人队列中，我们发现SLE患者通常有较差的身体表现。我们确定了SLE和非SLE特异性因素，这些因素可以帮助临床医生识别那些身体表现不佳的高危人群，并干预以改善、维持和支持SLE患者的身体表现。
ObjectiveTo report the burden and correlates of poor physical performance in a diverse cohort of individuals with systemic lupus erythematosus (SLE).MethodsIn this single‐visit study of 446 individuals with SLE from a population‐based metropolitan Atlanta cohort, we measured physical performance via the Short Physical Performance Battery (score range 0–12; intermediate‐low [<10] vs high [≥10]). We also collected demographic, clinical, and psychosocial variables and examined the associations (adjusted odds ratios [aORs]) of intermediate‐low versus high physical performance with these characteristics via multivariable logistic regression.ResultsWe found that more than half (59.6%) of our participants had poorer (intermediate‐low) overall physical performance. Only 7% of the cohort received the maximum score on the lower body strength task versus 90% and 76% receiving the maximum scores on balance and gait speed tasks. Current employment status (aOR 0.69, 95% confidence interval [CI] 0.45–1.05) and higher cognitive functioning (aOR 0.57, 95% CI 0.42–0.77) were strongly associated with lower odds of intermediate‐low physical performance. Higher body mass index (aOR 1.25, 95% CI 1.01–1.56), disease activity (aOR 1.59, 95% CI 1.27–1.98), and disease burden (aOR 1.38, 95% CI 1.08–1.77) were associated with poorer performance, as were higher depressive symptoms, perceived stress scores, and lower educational attainment (not statistically significant).ConclusionIn our population‐based, primarily Black cohort, we found that individuals with SLE commonly had poor physical performance. We identified both SLE‐ and non‐SLE–specific factors that could help clinicians identify those most at risk for poor physical performance and intervene to improve, maintain, and support physical performance among those with SLE.