Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research
Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research
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DOI：
10.1016/j.genhosppsych.2011.02.007
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发表时间：
2011-05-01
影响因子：
7
通讯作者：
de Jonge, Peter
中科院分区：
文献类型：
--
作者：
Meijer, Anna;Conradi, Henk Jan;de Jonge, Peter
目的：对25年来有关心肌梗死后抑郁与心脏预后关系的研究进行荟萃分析，以了解这种关系随时间的变化以及亚组效应。方法：进行系统的文献检索(Medline、Embase和QicINFO；1975-2011)，不受语言限制。调查心肌梗死后抑郁对心血管结果的影响的研究，被定义为指数MI后24个月内的全因死亡率、心脏死亡率和心脏事件。抑郁必须在心梗后3个月内使用现有的工具进行评估。采用随机效应模型计算合并优势比(OR)。结果：共确定29项研究，结果为41项比较。对16,889名心肌梗塞患者进行了随访(平均16个月)。心肌梗死后抑郁与全因死亡风险增加相关[(OR)，2.25；95%可信区间[CI]，1.73-2.93；P
Objective: A meta-analysis of over 25 years of research into the relationship between post-myocardial infarction (MI) depression and cardiac prognosis was conducted to investigate changes in this association over time and to investigate subgroup effects.Method: A systematic literature search was performed (Medline, Embase and PsycINFO; 1975-2011) without language restrictions. Studies investigating the impact of post-MI depression on cardiovascular outcome, defined as all-cause mortality, cardiac mortality and cardiac events within 24 months after the index MI, were identified. Depression had to be assessed within 3 months after MI using established instruments. Pooled odds ratios (ORs) were calculated using a random effects model.Results: A total of 29 studies were identified, resulting in 41 comparisons. Follow-up (on average 16 months) was described for 16,889 MI patients. Post-MI depression was associated with an increased risk of all-cause mortality [(OR), 2.25; 95% confidence interval [Cl], 1.73-2.93; P