Near-infrared optical imaging of the breast with model-based reconstruction
Near-infrared optical imaging of the breast with model-based reconstruction
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DOI：
10.1016/s1076-6332(03)80169-1
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发表时间：
2002-02-01
影响因子：
4.8
通讯作者：
Klove, KL
中科院分区：
文献类型：
--
作者：
Jiang, HB;Iftimia, NV;Klove, KL
理由和目标。近红外漫射光学成像可以提供比现有技术更高的对比度分辨率，用于检测和诊断乳腺癌。作者报告了使用近红外连续波断层扫描数据的基于模型的重建方法的定量吸收和散射图像。自动档的使用多通道光学成像系统对9名妇女的乳房进行成像：4名患有浸润性导管癌。1例为浸润性小叶癌，1例为纤维腺瘤，3例为无乳腺病变的对照组。图像重建方法以光子在乳腺组织中扩散的有限元法为核心。观察到肿瘤和邻近实质之间的实质性对比。对照受试者的图像显示出均匀的光学特征。在6例乳腺病变患者中，光学成像的肿瘤位置和大小准确，与钼靶X线检查结果一致。这项初步研究的结果表明，小至5分钟的癌症可以定量成像。此外，从散射图像的初步数据表明，良性和恶性肿瘤，他可以无创性区分与光学成像。
Rationale and Objectives. Near-infrared diffuse optical imaging may offer enhanced contrast resolution over that of the existing technologies for detection and diagnosis of breast cancer. The authors report quantitative absorption and scattering images of the human breast with model-based reconstruction methods using near-infrared continuous-wave tomographic data.Materials and Methods. An automatic. multichannel optical imaging system was used to image the breasts of nine women: four with infiltrating ductal carcinomas. one with infiltrating lobular carcinoma, one with fibroadenoma, and three control with no breast lesion. The image reconstruction methods are centered on the finite element of photon diffusion in breast tissue.Results. Substantial contrast between tumor and adjacent parenchyma as observed. Images of the control subjects showed homogeneous optical features. In the six women with breast lesions, the locations and sizes of tumors imaged optically were accurate and consistent with the mammographic findings.Conclusion. The results of this pilot study show that cancers as small as 5 min can he quantitatively imaged. In addition, preliminary data from the scattering images suggest that benign and malignant tumors can he noninvasively differentiated with optical imaging.