Sensory Impairment in Obese Patients? Sensitivity and Pain Detection Thresholds for Electrical Stimulation After Surgery-induced Weight Loss, and Comparison With a Nonobese Population
Sensory Impairment in Obese Patients? Sensitivity and Pain Detection Thresholds for Electrical Stimulation After Surgery-induced Weight Loss, and Comparison With a Nonobese Population
复制标题
DOI：
10.1097/ajp.0b013e31824786ad
复制
发表时间：
2013-01-01
影响因子：
2.9
通讯作者：
Lloret-Linares, Celia
中科院分区：
文献类型：
--
作者：
Dodet, Pauline;Perrot, Serge;Lloret-Linares, Celia
简介：肥胖患者疼痛性肌肉骨骼疾病的患病率很高，在大量减肥后可能会减少。肥胖者的疼痛阈值可能不同。目的：通过应用电敏感性评估大规模减肥前后的敏感性和疼痛检测阈值，并将获得的阈值与对照人群的阈值进行比较。方法：在31名肥胖者中测定了接受电刺激的参与者获得的敏感性和疼痛检测阈值。（年龄：40.3 +/- 10.5岁）之前（体重指数：45.7 +/- 6.8 kg/m2）和6个月后，胃旁路术诱导的平均体重减轻32 kg。将获得的结果与49名非肥胖对照参与者（38.5 ± 11.2岁;体重指数：22.6 ± 2.6 kg/m2）进行比较。评估了身体成分和代谢生物标志物，如瘦素、脂联素、胰岛素和白细胞介素6，并评估了μ阿片受体[OPRM 1]的单核苷酸多态性。（c.118A>G）和COMT（p.Val158 Met）]进行基因分型。（3.9 +/- 1.1; 11.6 +/- 6.0）在肥胖参与者中分别显著高于非肥胖参与者（3.1 +/- 1.1; 6.0 +/- 3.0）（P < 0.0001），并且不受体重急剧减轻的影响（平均变化：32 kg）。肥胖参与者的疼痛阈值与研究的任何临床和生物学变量无关。肥胖的参与者在最高的四分位数的敏感性和疼痛检测阈值显着老年人比那些在最低的quartile.Conclusions：需要进一步的研究，以探讨感觉功能障碍的肥胖个体，并调查这种功能障碍的影响疼痛管理。
Introduction: Obese patients have a high prevalence of painful musculoskeletal disorders that may decrease after massive weight loss. Pain thresholds may be different in obese participants.Objectives: To assess the sensitivity and pain detection thresholds, through the application of an electrical sensitivity, before and after massive weight loss, and to compare the thresholds obtained with those in a control population.Methods: The sensitivity and pain detection thresholds obtained in participants subjected to electrical stimulation were determined in 31 obese individuals (age: 40.3 +/- 10.5 y) before (body mass index: 45.7 +/- 6.8 kg/m(2)) and 6 months after a mean weight loss of 32 kg induced by gastric bypass. The results obtained were compared with those for 49 nonobese control participants (38.5 +/- 11.2 y; body mass index: 22.6 +/- 2.6 kg/m(2)). Body composition and metabolic biomarkers, such as leptin, adiponectin, insulin, and interleukin 6, were assessed and single-nucleotide polymorphisms of the mu opioid receptor [OPRM1 (c.118A>G) and COMT (p.Val158 Met)] were genotyped in obese patients.Results: Sensitivity and pain detection thresholds (3.9 +/- 1.1; 11.6 +/- 6.0) were significantly higher in obese than in nonobese participants (3.1 +/- 1.1; 6.0 +/- 3.0), respectively (P < 0.0001), and were not affected by drastic weight loss (mean change: 32 kg). Pain thresholds in obese participants were not correlated with any of the clinical and biological variables studied. The obese participants in the highest quartile for both sensitivity and pain detection thresholds were significantly older than those in the lowest quartile.Conclusions: Further studies are required to explore sensory dysfunction in obese individuals and to investigate the implications of this dysfunction for pain management.