Positive anti-cyclic citrullinated proteins and rheumatoid factor during active lung tuberculosis
Positive anti-cyclic citrullinated proteins and rheumatoid factor during active lung tuberculosis
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DOI：
10.1136/ard.2005.045229
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发表时间：
2006-08-01
影响因子：
27.4
通讯作者：
Caspi, D.
中科院分区：
文献类型：
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作者：
Elkayam, O.;Segal, R.;Caspi, D.
目的：检测肺结核患者血清中抗环瓜氨酸蛋白(抗CCP)和类风湿因子(RF)的水平，并与健康对照组进行比较。采用问卷调查法收集患者的临床特征、症状持续时间、发热、咳嗽、关节痛、肌痛、干燥症状等资料。治疗前采集患者血清标本，220℃冰冻，用ELISA检测抗-CCP和IgM-RF。结果：结核病相关症状平均持续4.4(1.7)个月，73%有发热，94%有咳嗽。风湿症状相对罕见：关节痛(4%)，肌痛(4%)，眼干和口干(分别为2%和9%)。肺结核患者抗CCP平均水平显著高于对照组：44.9Iuv20(7.3Iu)(p=0.002)。15/47(32%)患者的血清>；40U水平高于1/39(2.6%)的对照组(p=0.002)。TB患者血清平均(SD)IgMRF水平显著升高：17.8(19)v4.3(5)(p<；0.0001)。IgM-RF阳性者29/47(62%)，对照组1/39(2.6%)(P<；0.0001)。结论：活动性肺结核患者抗-CCP和IgM-RF滴度明显升高。
Objectives: To determine the prevalence of anti-cyclic citrullinated proteins ( anti-CCP) and IgM rheumatoid factor ( RF) in sera of patients with TB compared with healthy controls.Patients and methods: 47 consecutive patients with recently diagnosed active pulmonary TB and 39 healthy controls were studied. Data were collected by questionnaire on clinical features of the disease, duration of symptoms, fever, cough, arthralgia, myalgia, sicca symptoms. Serum samples were collected from patients before starting treatment for TB and frozen at 220 C. Anti-CCP and IgM RF were evaluated by ELISA.Results: The mean ( SD) duration of TB related symptoms was 4.4 ( 1.7) months, 73% had fever, 94% a cough. Rheumatic symptoms were relatively rare: arthralgia ( 4%), myalgias ( 4%), eye and mouth dryness ( 2% and 9%, respectively). Mean ( SD) levels of anti-CCP were significantly increased in patients with TB compared with controls: 44.9 ( 51) IU v 20 ( 7.3) IU ( p = 0.002). Serum levels > 40 U were found in 15/47 ( 32%) patients compared with 1/39 ( 2.6%) controls ( p = 0.002). Mean ( SD) serum levels of IgM RF were significantly increased in patients with TB: 17.8 ( 19) v 4.3 ( 5) ( p < 0.0001). IgM RF was positive (> 6 IU) in 29/47 ( 62%) patients v 1/39 ( 2.6%) controls ( p < 0.0001).Conclusions: A significant proportion of patients with active TB have an increased titre of anti-CCP and IgM RF.