Mathematical Modeling of irreversible Electroporation for treatment planning
Mathematical Modeling of irreversible Electroporation for treatment planning
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DOI：
10.1177/153303460700600403
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发表时间：
2007-08-01
影响因子：
2.8
通讯作者：
Davalos, Rafael V.
中科院分区：
文献类型：
--
作者：
Edd, Jon F.;Davalos, Rafael V.
不可逆电穿孔 (IRE) 是一种新的无药物方法，用于消融癌症治疗中特殊用途的不良组织。 IRE 通过一系列电脉冲实现目标组织内的细胞死亡，这些电脉冲将跨膜电位提高到永久损害整个治疗区域的脂质双层的程度。虽然 IRE 手术很容易执行，但治疗计划却很复杂，因为组织内的电场分布是控制 IRE 范围的最大单一因素，它很大程度上取决于电极配置、脉冲参数和任何组织异质性。为了解决这个困难，我们指导如何正确建模 IRE 并讨论建模在设计治疗方案中的好处。通过对电化学疗法中两种经典双电极结构：同轴盘电极和平行针电极的详细分析，介绍和讨论了必要的理论基础。还提供了这些情况的无量纲数据，只需插入适当的物理属性值和脉冲参数（例如电极间距、尺寸和脉冲幅度），就可以在各种条件下确定细胞常数、治疗区域和加热细节，以实现均匀的组织。还讨论了复杂性，例如异质组织和电穿孔引起的电导率变化。这些细节的综合可以由外科医生直接用于治疗计划。不可逆电穿孔是一种很有前途的新技术，可以在不使用药物的情况下以靶向方式治疗癌症；然而，它确实需要详细了解电流如何在生物组织内流动。通过提供设计 IRE 方案所需的理解和工具，本研究旨在促进将这种令人兴奋的新型癌症疗法转化为临床实践。
Irreversible Electroporation (IRE) is a new drug-free method to ablate undesirable tissue of particular use in cancer therapy. IRE achieves cell death within the targeted tissue through a series of electric pulses that elevate the transmembrane potentials to an extent that permanently damages the lipid bilayers throughout the treated region. Although the IRE procedure is easy to perform, treatment planning is complicated by the fact that the electric field distribution within the tissue, the greatest single factor controlling the extents of IRE, depends non-trivially on the electrode configuration, pulse parameters and any tissue heterogeneities. To address this difficulty, we instruct on how to properly model IRE and discuss the benefit of modeling in designing treatment protocols. The necessary theoretical basis is introduced and discussed through the detailed analysis of two classic dual-electrode configurations from electrochemotherapy: coaxial disk electrodes and parallel needle electrodes. Dimensionless figures for these cases are also provided that allow cell constants, treated areas, and the details of heating to be determined for a wide range of conditions, for uniform tissues, simply by plugging in the appropriate physical property values and pulse parameters such as electrode spacing, size, and pulse amplitude. Complexities, such as heterogeneous tissues and changes in conductivity due to electroporation, are also discussed. The synthesis of these details can be used directly by surgeons in treatment planning. Irreversible electroporation is a promising new technique to treat cancer in a targeted manner without the use of drugs; however, it does require a detailed understanding of how electric currents flow within biological tissues. By providing the understanding and tools necessary to design an IRE protocol, this study seeks to facilitate the translation of this new and exciting cancer therapy into clinical practice.