Trajectories of function and biomarkers with age: the CHS All Stars Study
Trajectories of function and biomarkers with age: the CHS All Stars Study
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DOI：
10.1093/ije/dyw092
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发表时间：
2016-08-01
影响因子：
7.7
通讯作者：
Arnold, Alice M.
中科院分区：
文献类型：
--
作者：
Newman, Anne B.;Sanders, Jason L.;Arnold, Alice M.
背景：多病是身体和认知障碍的主要驱动因素，但其下降速度也与衰老有关。我们试图通过疾病状态确定一个大型队列的衰退轨迹，并检查它们与衰老过程的生物标志物的对应关系，包括生长激素、性类固醇、炎症、内脏脂肪和肾功能途径。方法：自1989- 1990年以来，我们对5888名心血管健康研究（CHS）参与者进行了健康老龄化和长寿随访。步态速度、握力、改良迷你精神状态检查（3MSE）和数字符号替换测试（DSST）每年评估一次至1998-99年，2005-06年再次评估一次。对保存的样品进行胰岛素样生长激素（IGF-1）、硫酸脱氢表雄酮（DHEAS）、白细胞介素-6 （IL-6）、脂联素和胱抑素- c检测3-5次。健康状况每年更新一次，并分为健康与不健康。每个功能测量和生物标志物的轨迹使用广义估计方程作为年龄和健康状态的函数，使用标准化值进行估计。结果：在健康的老年男性和女性以及慢性病老年人中，功能衰退的轨迹显示出强烈的年龄加速。脂联素、IL-6和胱抑素- c与各功能域的功能下降有关；胱他汀- c始终与功能下降相关，独立于其他生物标志物。DHEAS与握力独立相关，IL-6与握力和步态速度轨迹独立相关。结论：晚年的功能衰退似乎标志着一个基本的衰老过程，无论健康状况如何，它都在晚年发生并加速。胱抑素C与这些功能下降的关系最为一致。
Background: Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.Methods: We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.Results: Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.Conclusion: Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines.