Forced normalization at the interface between epilepsy and psychiatry
Forced normalization at the interface between epilepsy and psychiatry
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DOI：
10.1016/s1525-5050(02)00052-5
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发表时间：
2002-08-01
影响因子：
2.6
通讯作者：
Kanner, AM
中科院分区：
文献类型：
--
作者：
Krishnamoorthy, ES;Trimble, MR;Kanner, AM
1953年，Landolt描述了一组控制不佳的癫痫患者，他们有精神病发作，癫痫发作缓解，脑电图上癫痫样活动消失。他把这种现象称为“强制正常化”。从那以后，神经学家和精神科医生对这种现象很感兴趣，尽管也有其他人报道过，但它的存在仍然是许多争论的来源。在本文中，我们回顾了强迫正常化的临床特征和潜在的致病机制，并说明了达到这种诊断的复杂性，以及在两个代表性病例中的鉴别诊断。(C) 2002 Elsevier Science （USA）。版权所有。
In 1953, Landolt described a group of patients with poorly controlled epilepsy who had psychotic episodes associated with remission of their seizures and disappearance of epileptiform activity on their EEGs. He called this phenomenon "forced normalization." Since then, neurologists and psychiatrists have been intrigued by this phenomenon, and although it has been also reported by others, its existence continues to be the source of much debate. In this article, we review the clinical characteristics and potential pathogenic mechanisms of forced normalization and illustrate the complexities inherent in reaching this diagnosis, as well as its differential diagnosis in two representative cases. (C) 2002 Elsevier Science (USA). All rights reserved.