White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism
White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism
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DOI：
10.1111/j.1469-7610.2009.02086.x
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发表时间：
2009-09-01
影响因子：
7.6
通讯作者：
McAlonan, G. M.
中科院分区：
文献类型：
--
作者：
Cheung, C.;Chua, S. E.;McAlonan, G. M.
背景：自闭症患者在三个领域存在障碍：沟通、社交互动和重复行为。我们之前的工作表明前额叶-纹状体-颞叶-小脑网络存在早期结构和连接异常，但尚不清楚这些与诊断指标的关系。方法：使用弥散张量成像对 6 至 14 岁的自闭症儿童（智商 > 70）和匹配的典型发育对照进行研究。使用基于体素的方法比较各组的分数各向异性 (FA) 测量值，并将自闭症组的 FA 测量值与 ICD-10 的自闭症诊断访谈 - 修订版 (ADI-R) 算法描述的诊断表型相关联。结果：在控制年龄和白质体积的影响后，我们发现自闭症组的双侧前额叶和颞叶区的 FA 显着低于对照组，尤其是在右腹侧颞叶邻近梭状回的叶。自闭症患者右额下回和左枕叶的 FA 较高。我们观察到，从这些群体差异的焦点区域延伸的白质束中，较低的 FA 和较高的 ADI-R 诊断算法分数之间存在紧密相关性。沟通和社会互惠障碍与整个额-纹状体-颞叶通路的 FA 较低相关。重复行为与更多后脑通路中的白质指数相关，包括胼胝体压部和小脑。结论：我们的数据支持自闭症的诊断症状与白质发育的核心破坏相关的立场。
Background:Individuals with autism have impairments in 3 domains: communication, social interaction and repetitive behaviours. Our previous work suggested early structural and connectivity abnormalities in prefrontal-striato-temporal-cerebellar networks but it is not clear how these are linked to diagnostic indices.Method:Children with autism (IQ > 70) aged 6 to 14 years old and matched typically developing controls were studied using diffusion tensor imaging. Voxel-based methods were used to compare fractional anisotrophy (FA) measures in each group and to correlate FA measures in the autism group with the diagnostic phenotype described by the Autism Diagnostic Interview - Revised (ADI-R) algorithm for ICD-10.Results:After controlling for the effects of age and white matter volume, we found that FA in the autism group was significantly lower than controls in bilateral prefrontal and temporal regions, especially in the right ventral temporal lobe adjacent to the fusiform gyrus. FA was greater in autism in the right inferior frontal gyrus and left occipital lobe. We observed a tight correlation between lower FA and higher ADI-R diagnostic algorithm scores across white matter tracts extending from these focal regions of group difference. Communication and social reciprocity impairments correlated with lower FA throughout fronto-striato-temporal pathways. Repetitive behaviours correlated with white matter indices in more posterior brain pathways, including splenium of the corpus callosum and cerebellum.Conclusions:Our data support the position that diagnostic symptoms of autism are associated with a core disruption of white matter development.