INTERFERENCE BY HUMAN AND BOVINE SERUM AND SERUM PROTEIN FRACTIONS WITH THE ABSORPTION OF ANTIBODIES BY SUCKLING RATS AND MICE
INTERFERENCE BY HUMAN AND BOVINE SERUM AND SERUM PROTEIN FRACTIONS WITH THE ABSORPTION OF ANTIBODIES BY SUCKLING RATS AND MICE
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DOI：
10.1098/rspb.1958.0046
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发表时间：
1958-01-01
期刊：
影响因子：
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通讯作者：
MORRIS, IG
中科院分区：
文献类型：
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作者：
BRAMBELL, FWR;HALLIDAY, R;MORRIS, IG
哺乳期的大鼠和小鼠主要通过乳汁从母体获得被动免疫力。抗体也通过口服免疫血清进入循环。某些物种的血清，包括兔、人和牛，当与经口给予的免疫血清混合时，相对于与同源非免疫血清的类似混合物，已显示减少抗体的进入。这种效应被称为干扰。结果表明，人或牛血清中的7-球蛋白组分在缓冲盐水中的浓度与血清中的浓度大致相当，在干扰抗体（无论是同源的还是异源的）的传递方面与全血清一样有效。人或牛血清的白蛋白组分不干扰，缓冲盐水也不干扰。相对于免疫球蛋白，γ-球蛋白的含量必须相当高才有效。如果与免疫血清同时给药，它是最有效的，如果超过四小时前给药，它是无效的。理论上的影响的结果进行了讨论，并提出了一个假设。
Suckling rats and mice derive passive immunity from the mother, mainly by way of the milk. Antibodies pass into the circulation also from immune serum administered by mouth. The sera of certain species, including rabbit, man and ox, when mixed with the immune serum administered by mouth, have been shown to reduce the entry of antibodies, relative to similar admixture with homologous non-immune serum. This effect was called interference. It is shown that the 7-globulin fraction of either human or bovine serum, at concentrations in buffered saline approximately equivalent to those in serum, is as effective as whole serum in interfering with the transmission of antibodies, whether homologous or heterologous. The albumin fraction of either human or bovine serum does not interfere, nor does buffered saline. The [gamma]-globulin must be present in considerable quantity relative to the immune globulin to be effective. It is most effective if administered at the same time as the immune serum and is ineffective if administered more than four hours previously. The theoretical implications of the results are discussed and a hypothesis is suggested.