Measurements of vocal fold elasticity using the linear skin rheometer
Measurements of vocal fold elasticity using the linear skin rheometer
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DOI：
10.1159/000091734
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发表时间：
2006-01-01
影响因子：
1
通讯作者：
Goodyer, Eric
中科院分区：
文献类型：
--
作者：
Hess, Markus M.;Mueller, Frank;Goodyer, Eric
目的：将测量皮肤粘弹性的线性皮肤流变仪（LSR）用于声带特性的测量。对动物和人类切除的喉进行了一系列研究，以确定LSR技术是否可以应用于声带。方法：在切除的喉中，使用小探针以0.3 Hz在1-2 mm的距离内正弦驱动小块粘膜。1 g当量的力给出了最佳测量。刚度和粘度值来自应力/应变数据。结果如下：该仪器能够以可重复的方式测量组织的粘弹性，并且可以检测组织被人为硬化的区域。喉粘膜的机械性能的二维地图，显示在弹性平行和垂直于声带边缘的局部变化。最初的研究是使用动物组织进行的;最近，LSR已成功地用于从人体组织中获得类似的数据。结论：LSR能够以可重复和可靠的方式测量声带的弹性特性。现在将进行进一步的研究，以从更大的人体组织样本中获得数据。版权所有（c）2006 S. Karger AG，巴塞尔。
Objective: The linear skin rheometer (LSR), which measures skin visco-elasticity, was adapted for measurements of vocal fold properties. A series of studies was performed on animal and human excised larynges to determine if the LSR technique can be applied to the vocal fold. Methods: In excised larynges, small patches of mucosa were driven sinusoidally at 0.3 Hz over distances of 1-2 mm using a small probe. Forces in the order of 1 g equivalent gave optimal measurements. Stiffness and viscosity values were derived from stress/strain data. Results: The instrument was able to measure the visco-elasticity of the tissue in a repeatable manner and it could detect areas where the tissue was artificially stiffened. Two-dimensional maps of the mechanical properties of the laryngeal mucosa were obtained showing local variations in elasticity both parallel and perpendicular to the vocal fold edge. Initial studies were undertaken using animal tissue; more recently, the LSR has been successfully used to obtain similar data from human tissue. Conclusion: The LSR was been demonstrated to be capable of measuring the elastic properties of the vocal fold in a repeatable and reliable manner. Further studies will now be undertaken to obtain data from a larger sample of human tissue. Copyright (c) 2006 S. Karger AG, Basel.