Creatine kinase values in amyotrophic lateral sclerosis
Creatine kinase values in amyotrophic lateral sclerosis
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DOI：
10.1016/s0022-510x(98)00195-6
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发表时间：
1998-10-01
影响因子：
4.4
通讯作者：
North, WA
中科院分区：
文献类型：
--
作者：
Felice, KJ;North, WA
在该中心运动神经元疾病诊所连续就诊的217例（65%）患者中，有140例在确诊肌萎缩性侧索硬化症（ALS）时或确诊后不久记录了血清肌酸激酶（CK1）值。140例ALS患者中有48例（34%）在病程后期进行了第二次肌酸激酶（CK2）测定。CK1和CK2平均值（单位，乘以正常上限）分别为1.22（范围0.1 ~ 3.0，中位数0.80）和1.34（范围0.1 ~ 9.2，中位数0.80）（P=0.11, r=0.92，平均差值=28.2%）。在140例ALS患者中，58例（41%）（男女比例：2.9:1.0）CK1值升高，范围从1.03到13.0（平均2.21，中位数1.67）。12例（8.6%）患者CK1值大于3.0。男性ALS患者（平均1.56）的平均CK1值显著高于女性（平均0.80）（P=0.001），肢体发病（平均1.34）的CK1值显著高于球茎发病（平均0.80）的CK1值（P=0.009）。CK1值与发病年龄或生存期相关性较差，且不能预测。(C) 1998 Elsevier Science B.V.版权所有
Serum creatine kinase (CK1) values were recorded while or soon after the diagnosis of amyotrophic lateral sclerosis (ALS) was established in 140 of 217 (65%) consecutive patients seen in the Motor Neuron Disease Clinic at this center during a 5-year period. Second creatine kinase (CK2) determinations were recorded on 48 of 140 (34%) ALS patients later in the course of the disease. The mean CK1 and CK2 values (unit, times the upper limit of normal) were 1.22 (range, 0.1 to 3.0; median, 0.80) and 1.34 (range, 0.1-9.2; median, 0.80) (P=0.11, r=0.92, mean difference=28.2%). Of the 140 ALS patients, 58 (41%) (male:female ratio: 2.9:1.0) had elevated CK1 values ranging from 1.03 to 13.0 (mean, 2.21; median, 1.67). Twelve patients (8.6%) had CK1 values greater than 3.0. Mean CK1 values were significantly greater (P=0.001) in male (mean, 1.56) versus female (mean, 0.80) ALS patients, and significantly greater (P=0.009) in limb-onset (mean, 1.34) versus bulbar-onset (mean, 0.80) disease. CK1 values correlated poorly with and were not predictive of age of onset or survival. (C) 1998 Elsevier Science B.V. All rights reserved.