Insulin-like growth factor binding protein-I-6 expression in activated microglia
Insulin-like growth factor binding protein-I-6 expression in activated microglia
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DOI：
10.1097/00001756-200404290-00020
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发表时间：
2004-04-29
期刊：
影响因子：
1.7
通讯作者：
De Keyser, J
中科院分区：
文献类型：
--
作者：
Chesik, D;Glazenburg, K;De Keyser, J
In the CNS insulin-like growth factor-1 (IGF-1) enhances survival of neurons, promotes myelin synthesis and acts as a mitogen for microglia. The effects of IGF-1 are regulated by a family of 6 IGF binding proteins (IGFBPs). We investigated mRNA expression patterns of IGFBPs in primary rat microglia under basal conditions and after activation with lipopolysaccharide (LPS). Under basal conditions, microglia expressed IGFBP-2 to -6, whereas, IGFBP-1 could not be detected. Following 2 h treatment with LPS mRNA levels for IGFBP-4 and -6 displayed a down regulation, and IGFBP-5 became undetectable. Levels of IGFBP-2 and -3 remained unaltered. Expression patterns of IGFBPs might play an important role in regulating the autocrine/paracrine IGF-1 actions on microglia under inflammatory conditions.
