Regulation of cellular iron metabolism.
Regulation of cellular iron metabolism.
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DOI：
10.1042/bj20101825
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发表时间：
2011-03-15
期刊：
影响因子：
--
通讯作者：
Pantopoulos K
中科院分区：
文献类型：
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作者：
Wang J;Pantopoulos K
铁是一种必需但具有潜在危险的生物金属。哺乳动物细胞需要足够量的铁来满足代谢需求或完成特殊功能。铁通过循环转铁蛋白输送到组织，转铁蛋白是一种转运蛋白，可捕获主要从肠肠上皮细胞或网状内皮巨噬细胞释放到血浆中的铁。载铁转铁蛋白与细胞表面转铁蛋白受体 1 的结合导致金属货物的内吞作用和摄取。内化的铁被转运到线粒体以合成血红素或铁硫簇，它们是几种金属蛋白的组成部分，过量的铁在胞质铁蛋白中储存和解毒。铁代谢受到不同水平和不同机制的控制。本综述总结了铁转运、使用和储存的基本概念，重点关注IRE（铁反应元件）/IRP（铁调节蛋白）系统，这是一种众所周知的转录后调节回路，不仅维持各种细胞类型中的铁稳态，而且有助于全身铁平衡。
Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is delivered to tissues by circulating transferrin, a transporter that captures iron released into the plasma mainly from intestinal enterocytes or reticuloendothelial macrophages. The binding of iron-laden transferrin to the cell-surface transferrin receptor 1 results in endocytosis and uptake of the metal cargo. Internalized iron is transported to mitochondria for the synthesis of haem or iron–sulfur clusters, which are integral parts of several metalloproteins, and excess iron is stored and detoxified in cytosolic ferritin. Iron metabolism is controlled at different levels and by diverse mechanisms. The present review summarizes basic concepts of iron transport, use and storage and focuses on the IRE (iron-responsive element)/IRP (iron-regulatory protein) system, a well known post-transcriptional regulatory circuit that not only maintains iron homoeostasis in various cell types, but also contributes to systemic iron balance.