MAIL, a novel nuclear IκB protein that potentiates LPS-induced IL-6 production
MAIL, a novel nuclear IκB protein that potentiates LPS-induced IL-6 production
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DOI：
10.1016/s0014-5793(00)02185-2
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发表时间：
2000-11-17
期刊：
影响因子：
3.5
通讯作者：
Saito, M
中科院分区：
文献类型：
--
作者：
Kitamura, H;Kanehira, K;Saito, M
我们已经鉴定并鉴定了一个新的锚定重复序列家族成员，命名为“具有由脂多糖诱导的锚定重复序列的分子”（MAIL）。MAIL的C-末端部分与I κ B家族有很高的同源性。腹腔注射脂多糖（LPS）迅速（< 0.5 h）诱导MAIL mRNA在各种组织中表达，特别是在脾、淋巴结和肺中。在Swiss 3 T3细胞中，MAIL定位于细胞核内，并能显著增强LPS诱导的IL-6的表达和分泌。这些结果表明MAIL是细胞核内的IB蛋白之一，是IL-6产生的激活剂。(C)2000年欧洲生物化学学会联合会。由Elsevier Science B. V.出版，版权所有。
We have identified and characterized a novel member of the ankyrin-repeat family named 'molecule possessing ankyrin-repeats induced by lipopolysaccharide' (MAIL). The C-terminal portion of MAIL shared high sequence homology,vith the I kappaB family. Intraperitoneal injection of lipopolysaccharide (LPS) into mice rapidly (< 0.5 h) induced MAIL mRNA in various tissues, particularly in the spleen, lymph node, and lung. Ectopically expressed MAIL was localized in the nucleus, and remarkably potentiated the LPS-induced mRNA expression and secretion of interleukin (IL)-6 in Swiss 3T3 cells, These findings indicate that MAIL is one of the nuclear IB proteins and an activator of IL-6 production. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.