Update on endogenous inhibitors of angiogenesis
Update on endogenous inhibitors of angiogenesis
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DOI：
10.1080/1062332060069110
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发表时间：
2006-03-01
影响因子：
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通讯作者：
Sato, Yasufumi
中科院分区：
文献类型：
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作者：
Sato, Yasufumi
血管生成受内源性血管生成刺激物和抑制物水平之间的局部平衡调节。自从发现血管生成刺激剂家族的两个成员，即，血管内皮生长因子家族蛋白和血管生成素。这些因子作用于内皮细胞以刺激血管生成。与此相反，大多数血管生成抑制剂似乎不具有这些特性。很少有基因编码的分子，选择性抑制血管生成已被发现。本文将重点介绍我们目前对内源性血管生成抑制剂的认识。
Angiogenesis is regulated by a local balance between the levels of endogenous stimulators and inhibitors of angiogenesis. Understanding of the mechanism of angiogenesis has advanced significantly since the discovery of two members of the family of angiogenesis stimulators, i.e., vascular endothelial growth factor family proteins and angiopoietins. These factors act on endothelial cells to stimulate angiogenesis. In contrast, most of angiogenesis inhibitors do not seem to have such characteristics. Very few genes encoding molecules that selectively inhibit angiogenesis have been discovered. This review will focus on our current understanding of endogenous inhibitors of angiogenesis.