Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence.
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence.
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扩展杏仁核中的去肾上腺素能传播：在持久的药物戒酒期间，在毒品寻求和复发中的作用。
DOI：
10.1007/s00429-008-0191-3
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发表时间：
2008-09
影响因子：
3.1
通讯作者：
Aston-Jones, Gary
中科院分区：
文献类型：
--
作者：
Smith, Rachel J.;Aston-Jones, Gary
本文回顾的研究表明，在长期戒毒期间，慢性药物暴露的负面情感状态和药物寻求增加涉及杏仁核的扩展。在杏仁核（包括终纹床核、杏仁核壳和杏仁核中央核）中的去甲肾上腺素（NE）和促肾上腺皮质激素释放因子（CRF）信号传导通常参与对环境和内部应激的行为反应。成瘾期间应激反应系统的过度活跃驱动了许多药物戒断的负面成分。特别是，NE信号从孤束核（NTS）的扩展杏仁核，沿着增加CRF传输的扩展杏仁核内，是至关重要的急性阿片类药物戒断的厌恶性，以及压力诱导的毒品寻求阿片类药物，可卡因，乙醇和尼古丁的复发。延长杏仁核中的NE和CRF传输也与长期戒断慢性阿片类药物、可卡因、乙醇和大麻素期间发生的焦虑增加有关。这些与压力相关的行为中的许多被NE或CRF拮抗剂逆转，所述NE或CRF拮抗剂在扩展的杏仁核内全身或局部给予。最后，延长杏仁核和NTS中Fos激活的增加与长期戒断阿片类药物和可卡因期间观察到的对药物的偏好增强和对自然奖励的偏好降低有关，表明这些区域参与了与成瘾相关的改变的奖励处理。总之，这些研究结果表明，扩展杏仁核及其去甲肾上腺素能传入神经参与焦虑，压力诱导的复发，并改变奖励处理反映了这些电路在寻求药物的压力调制的共同功能。
Studies reviewed here implicate the extended amygdala in the negative affective states and increased drug-seeking that occur during protracted abstinence from chronic drug exposure. Norepinephrine (NE) and corticotropin-releasing factor (CRF) signaling in the extended amygdala, including the bed nucleus of the stria terminalis, shell of the nucleus accumbens, and central nucleus of the amygdala, are generally involved in behavioral responses to environmental and internal stressors. Hyperactivity of stress response systems during addiction drives many negative components of drug abstinence. In particular, NE signaling from the nucleus tractus solitarius (NTS) to the extended amygdala, along with increased CRF transmission within the extended amygdala, are critical for the aversiveness of acute opiate withdrawal as well as stress-induced relapse of drug-seeking for opiates, cocaine, ethanol, and nicotine. NE and CRF transmission in the extended amygdala are also implicated in the increased anxiety that occurs during prolonged abstinence from chronic opiates, cocaine, ethanol, and cannabinoids. Many of these stress-associated behaviors are reversed by NE or CRF antagonists given systemically or locally within the extended amygdala. Finally, increased Fos activation in the extended amygdala and NTS is associated with the enhanced preference for drugs and decreased preference for natural rewards observed during protracted abstinence from opiates and cocaine, indicating that these areas are involved in the altered reward processing associated with addiction. Together, these findings suggest that involvement of the extended amygdala and its noradrenergic afferents in anxiety, stress-induced relapse, and altered reward processing reflects a common function for these circuits in stress modulation of drug-seeking.
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DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
影响因子：
3.4
作者：
Basso, AM;Spina, M;Koob, GF
通讯作者：
Koob, GF
影响因子：
16.2
作者：
Borgland, SL;Taha, SA;Bonci, A
通讯作者：
Bonci, A
影响因子：
64.5
作者：
Chemelli, RM;Willie, JT;Yanagisawa, M
通讯作者：
Yanagisawa, M
DOI：
10.1615/critrevneurobiol.v16.i12.130
发表时间：
2004-01-01
期刊：
Critical Reviews in Neurobiology
影响因子：
--
作者：
Carboni, Ezio;Silvagni, Alessandra
通讯作者：
Silvagni, Alessandra