Biosynthesis and structural revision of neomarinone
Biosynthesis and structural revision of neomarinone
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DOI：
10.1021/ol035748b
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发表时间：
2003-11-13
期刊：
影响因子：
5.2
通讯作者：
Moore, BS
中科院分区：
文献类型：
--
作者：
Kalaitzis, JA;Hamano, Y;Moore, BS
通过用c -13标记前体的饲养实验，探讨了海洋放线菌合成meroterpenoid neomarinone的过程。富含葡萄糖的[U-C-13(6)]新马麻子酮的核磁共振表征导致结构4a到4b的结构修正，这是通过广泛的二维核磁共振光谱与未标记的化合物证实的。
The biosynthesis of the meroterpenoid neomarinone from a marine actinomycete was probed through feeding experiments with C-13-labeled precursors. NMR characterization of [U-C-13(6)]glucose-enriched neomarinone led to the structural revision of structure 4a to 4b, which was confirmed by extensive 2D NMR spectrometry with unlabeled compound.