Aluminum Gallium Nitride (GaN)/GaN High Electron Mobility Transistor-Based Sensors for Glucose Detection in Exhaled Breath Condensate
Aluminum Gallium Nitride (GaN)/GaN High Electron Mobility Transistor-Based Sensors for Glucose Detection in Exhaled Breath Condensate
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DOI：
10.1177/193229681000400122
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发表时间：
2010-01
影响因子：
5
通讯作者：
B. Chu;B. S. Kang;S. Hung;Ke-Hung Chen;F. Ren;A. Sciullo;B. Gila;S. Pearton
中科院分区：
文献类型：
--
作者：
B. Chu;B. S. Kang;S. Hung;Ke-Hung Chen;F. Ren;A. Sciullo;B. Gila;S. Pearton
背景资料：固定化氮化铝镓（AlGaN）/GaN高电子迁移率晶体管（HEMT）在呼出气冷凝物（EBC）中的pH、氯离子和葡萄糖检测领域显示出巨大的潜力。HEMT传感器可以集成到无线数据传输系统中，从而实现远程监控。该技术提供了使用AlGaN/GaN HEMT进行EBC中检测葡萄糖的气道病理学的扩展研究而无需临床访问的可能性。研究方法：HEMT结构由3 μ m厚的未掺杂GaN缓冲层、30 μ m厚的Al 03 Ga 07 N间隔层和220 μ m厚的硅掺杂Al 03 Ga 07 N盖层组成，用于制造HEMT传感器。pH、氯离子和葡萄糖检测的门区分别用氧化钪（Sc2 O3）、氯化银（AgCl）薄膜和氧化锌（ZnO）纳米棒固定。结果如下：Sc2 O3-门控传感器可以检测溶液的pH值范围从3到10，分辨率为0.1 pH。使用固定有AgCl薄膜的HEMT传感器，氯离子检测限为10 - 8 M。当传感器暴露于pH值为7.4的缓冲液中的目标葡萄糖时，固定有葡萄糖氧化酶的ZnO纳米棒栅控AlGaN/GaN HEMT传感器的漏源电流显示出小于5秒的快速响应。该传感器可以检测0.5 nM至125 μM的宽浓度范围。结论：基于HEMT的传感器在EBC中用于提高葡萄糖检测的检测灵敏度具有很大的前景。基于HEMT的传感器可用于感测不同的材料，这取决于固定的材料。这些电子检测方法具有快速响应和良好的重复性，显示了研究气道病理的潜力。这些设备还可以集成到无线数据传输系统中，用于远程监控应用。这种传感器技术可以使用呼出气冷凝物来测量糖尿病应用的葡萄糖浓度。
Background: Immobilized aluminum gallium nitride (AlGaN)/GaN high electron mobility transistors (HEMTs) have shown great potential in the areas of pH, chloride ion, and glucose detection in exhaled breath condensate (EBC). HEMT sensors can be integrated into a wireless data transmission system that allows for remote monitoring. This technology offers the possibility of using AlGaN/GaN HEMTs for extended investigations of airway pathology of detecting glucose in EBC without the need for clinical visits. Methods: HEMT structures, consisting of a 3-μm-thick undoped GaN buffer, 30-Å-thick Al03Ga07N spacer, and 220-Å-thick silicon-doped Al03Ga07N cap layer, were used for fabricating the HEMT sensors. The gate area of the pH, chloride ion, and glucose detection was immobilized with scandium oxide (Sc2O3), silver chloride (AgCl) thin film, and zinc oxide (ZnO) nanorods, respectively. Results: The Sc2O3-gated sensor could detect the pH of solutions ranging from 3 to 10 with a resolution of ∼0.1 pH. A chloride ion detection limit of 10−8 M was achievedt with a HEMT sensor immobilized with the AgCl thin film. The drain-source current of the ZnO nanorod-gated AlGaN/GaN HEMT sensor immobilized with glucose oxidase showed a rapid response of less than 5 seconds when the sensor was exposed to the target glucose in a buffer with a pH value of 7.4. The sensor could detect a wide range of concentrations from 0.5 nM to 125 μM. Conclusion: There is great promise for using HEMT-based sensors to enhance the detection sensitivity for glucose detection in EBC. Depending on the immobilized material, HEMT-based sensors can be used for sensingt different materials. These electronic detection approaches with rapid response and good repeatability show potential for the investigation of airway pathology. The devices can also be integrated into a wireless data transmission system for remote monitoring applications. This sensor technology could use the exhaled breath condensate to measure the glucose concentration for diabetic applications.