Axon Guidance Molecules Implicated in Early-Onset Obesity.
Axon Guidance Molecules Implicated in Early-Onset Obesity.
复制标题
轴突引导分子与早发性肥胖有关。
DOI：
10.1016/j.tins.2019.03.005
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发表时间：
2019
影响因子：
15.9
通讯作者：
Zeltser,LoriM
中科院分区：
文献类型：
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作者：
Zeltser,LoriM
母亲的营养状况和后代的早期生长速度影响黑皮质素系统的发育和后来对代谢失调的易感性，但很难评估因果关系。最近货车德Klaauwet的研究。（Cell2019; 176：729-742）提供了直接证据，表明干扰调节神经元回路形成的系统导致斑马鱼、小鼠和人类的早发性肥胖。
Maternal nutritional status and the early growth rates of offspring influence the development of the melanocortin system and later susceptibility to metabolic dysregulation, but it is difficult to assess causality. A recent study by van der Klaauwet al.(Cell2019;176:729–742) provides direct evidence that disrupting systems regulating neuronal circuit formation leads to early-onset obesity in zebrafish, mouse, and humans.