Skin autofluorescence for the risk assessment of chronic complications in diabetes: a broad excitation range is sufficient.
Skin autofluorescence for the risk assessment of chronic complications in diabetes: a broad excitation range is sufficient.
复制标题
皮肤自发荧光用于糖尿病慢性并发症的风险评估：广泛的激发范围就足够了。
DOI：
10.1364/oe.17.000509
复制
发表时间：
2009
期刊：
影响因子：
3.8
通讯作者：
R. Graaff
中科院分区：
文献类型：
--
作者：
M. Koetsier;H. Lutgers;A. Smit;T. Links;R. D. Vries;R. Gans;G. Rakhorst;R. Graaff
Skin autofluorescence (AF) is becoming an accepted clinical method for assessing the risk of chronic complications in diabetes mellitus (DM). In this study, the role of the excitation wavelength in the recognition of increased risk of diabetes-related chronic complications was investigated. An Excitation Emission Matrix Scanner (EEMS) was used to perform noninvasive measurements in four age-matched groups of patients with type 1 and type 2 DM, with and without chronic complications, as well as in a control group (N=97 in total). AF was calculated for excitation wavelengths in the range 355 - 405 nm. Mean spectra were assessed per group. AF values in both type 1 and type 2 DM patients with complications were increased compared to the control subjects (p < 0:01); this ratio remained practically constant, independent of the excitation wavelength. No emission peaks were distinctive for specific patient groups. We conclude that in these groups, no characteristic fluorophores dictate the use of a specific wavelength or set of wavelengths. The results show the validity of applying a broad excitation wavelength range for risk assessment of chronic complications in diabetes.
影响因子：
7.4
作者：
Baynes, JW;Thorpe, SR
通讯作者：
Thorpe, SR
影响因子：
3.8
作者：
Skala, Melissa C.;Palmer, Gregory M.;Ramanujam, Nirmala
通讯作者：
Ramanujam, Nirmala
影响因子：
13.6
作者：
Meerwaldt, R;Hartog, JWL;Smit, AJ
通讯作者：
Smit, AJ