DIFFERENTIAL EFFECT OF AMYGDALOID-LESIONS ON CRF-41, ACTH AND CORTICOSTERONE RESPONSES FOLLOWING NEURAL STIMULI
DIFFERENTIAL EFFECT OF AMYGDALOID-LESIONS ON CRF-41, ACTH AND CORTICOSTERONE RESPONSES FOLLOWING NEURAL STIMULI
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DOI：
10.1016/s0006-8993(09)90005-1
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发表时间：
1994-09-26
期刊：
影响因子：
2.9
通讯作者：
WEIDENFELD, J
中科院分区：
文献类型：
--
作者：
FELDMAN, S;CONFORTI, N;WEIDENFELD, J
本实验观察了大鼠杏仁核（AMG）毁损后正中隆起（ME）、CRF-41及血清ACTH和皮质酮（CS）水平的变化。在完整的动物光或声刺激引起CRF-41消耗从ME和血清ACTH和CS水平的上升。在内侧或中央AMG核病变的大鼠中，这些反应被阻断。基础AMG病变无效。此外，所有动物组对乙醚应激反应正常。这些结果表明AMG核对下丘脑-垂体-肾上腺皮质（HPA）轴的不同作用，并表明AMG核对HPA轴反应的易化作用涉及ME CRF-41的释放，其刺激ACTH，从而刺激CS分泌。
The effect of amygdaloid (AMG) lesions on changes in median eminence (ME) CRF-41 and serum ACTH and corticosterone (CS) levels following neural stimuli were investigated in rats. In intact animals photic or acoustic stimuli caused CRF-41 depletion from the ME and a rise in serum ACTH and CS levels. In rats with medial or central AMG nuclei lesions, these responses were blocked. Basal AMG lesions were not effective. Also, all groups of animals responded normally to ether stress. These results indicate a differential effect of AMG nuclei on the hypothalamo-pituitary-adrenocortical (HPA) axis and demonstrate that the facilitatory effect of the AMG nuclei on the HPA axis responses involves the release of ME CRF-41, which stimulates ACTH and consequently CS secretion.