LIVING WITH CLATHRIN - ITS ROLE IN INTRACELLULAR MEMBRANE TRAFFIC
LIVING WITH CLATHRIN - ITS ROLE IN INTRACELLULAR MEMBRANE TRAFFIC
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DOI：
10.1126/science.2904698
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发表时间：
1988-12-09
期刊：
影响因子：
56.9
通讯作者：
BRODSKY, FM
中科院分区：
文献类型：
--
作者：
BRODSKY, FM
在细胞膜的细胞质一侧的笼状蛋白聚合形成包被的凹坑和囊泡，它们介导细胞表面受体的摄取。笼状蛋白包裹的囊泡也与蛋白质输出有关，但对其确切作用的定义一直存在争议。近年来，对分子筛蛋白亚基和包膜囊泡成分的研究进展证实了分子间相互作用参与了分子筛蛋白聚合和包膜囊泡的形成，并为研究其功能提供了新的途径。这些研究表明，笼蛋白在向内和向外膜运输中的作用是通过浓度和分类过程促进受体的运输，该过程启动了针对特定细胞内隔室的靶向。
Clathrin polymerization at the cytoplasmic side of the plasma membrane forms coated pits and vesicles that mediate uptake of cell surface receptors. Clathrin-coated vesicles have also been implicated in protein export but definition of their precise role has been controversial. Recent advances in characterization of the clathrin subunits and additional coated vesicle components have identified molecular interactions involved in clathrin polymerization and coated vesicle formation, and have provided new approaches to investigating its function. These studies suggest that clathrin's role, in both inward and outward membrane traffic, is to facilitate receptor transport by a concentration and sorting process that initiates targeting to specific intracellular compartments.