Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial.
Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial.
复制标题
在一项随机对照试验中，在标准平衡与营养饮食中，人之间的体重减轻差异。
DOI：
10.1016/j.cgh.2015.02.044
复制
发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Zarrinpar A
中科院分区：
文献类型：
--
作者：
Frankwich KA;Egnatios J;Kenyon ML;Rutledge TR;Liao PS;Gupta S;Herbst KL;Zarrinpar A
许多公司提供与肥胖相关的多态性基因测试（营养遗传学），并根据结果提出减肥饮食建议。我们进行了一项随机对照试验，以确定在8周和24周内，营养指导饮食的参与者是否比标准均衡饮食的参与者体重减轻≥5%。我们对51名肥胖或超重的美国退伍军人进行了一项前瞻性研究，该研究采用了退伍军人管理局圣地亚哥医疗保健系统(MOVE！程序)。参与者被随机分配到营养指导饮食组（均衡、低碳水化合物、低脂或地中海饮食组；n=30）和标准均衡饮食组（n=21）。根据Pathway FIT测试（Pathway Genomics; San Diego， CA）的结果选择营养遗传饮食。均衡饮食组与营养指导饮食组在8周或24周时体重减轻5%的比例无显著差异（分别为35.0%±20.9% vs 26.9%±17.1%；P= 0.28）。两组人都很难坚持饮食。然而，坚持营养指导饮食与体重减轻相关（r=0.74； P= 4.0 × 10−5），但坚持标准治疗与体重减轻无关（r=0.34； P= 0.23）。具有肥胖低风险多态性的参与者在8周时比所有其他参与者减轻了更多的体重（分别为5.0%对2.9%，P= 0.02），并且在24周时体重指数（分别为6.4%对3.6%，P= 0.03）和腰围（分别为6.5%对2.6%，P= 0.02）的减少明显更大。在一项前瞻性研究中，与标准均衡饮食相比，以营养为基础的饮食并没有增加减肥的效果。然而，基因特征可以识别出最有可能从均衡饮食减肥策略中受益的个体；这些发现需要进一步调查。ClincialTrials.gov号码：NCT01859403
Many companies provide genetic tests for obesity-related polymorphisms (nutrigenetics) and make dietary recommendations for weight loss based on the results. We performed a randomized controlled trial to determine whether more participants who followed a nutrigenetic-guided diet lost ≥5% of their body weight than participants on a standard balanced diet, for 8 and 24 weeks. We performed a prospective study of 51 obese or overweight US veterans on an established weight management program at the Veterans Administration San Diego Healthcare System (the MOVE! Program). Participants were randomly assigned to groups placed on a nutrigenetic-guided diet (balanced, low-carbohydrate, low-fat, or Mediterranean; n=30) or a standard balanced diet (n=21). Nutrigenetic diets were selected based on results from the Pathway FIT test (Pathway Genomics; San Diego, CA). There was no significant difference in the percentage of participants on the balanced diet vs the nutrigenetic-guided diet who lost 5% of their body weight at 8 weeks (35.0%±20.9% vs 26.9%±17.1%, respectively; P=.28) or at 24 weeks. Both groups had difficulty adhering to the diets. However, adherence to the nutrigenetic-guided diet correlated with weight loss (r=0.74; P= 4.0 × 10−5), but not adherence to standard therapy (r=0.34; P=.23). Participants who had low-risk polymorphisms for obesity lost more weight than all other participants at 8 weeks (5.0% vs 2.9%, respectively; P=.02), and had significantly greater reductions in body mass index (6.4% vs 3.6% respectively; P=.03) and waist circumference (6.5% vs 2.6% respectively; P=.02) at 24 weeks. In a prospective study, a nutrigenetic-based diet did not increase weight loss compared with a standard balanced diet. However, genetic features can identify individuals most likely to benefit from a balanced diet weight loss strategy; these findings require further investigation. ClincialTrials.gov number: NCT01859403